Real-World Selection of Patients for Allogeneic HCT at a Single Centre: Lack of a Suitable Donor and Other Reasons for Not Proceeding
Simple Summary
Abstract
1. Introduction
2. Methods
2.1. Study Population and Design
2.2. Data Analysis
2.3. Outcomes
2.4. Haplostats
2.5. Duplicates
2.6. Donor Search Algorithm
3. Results
3.1. Characteristics of the Study Population
3.2. Transplanted Patients
3.3. Referrals That Did Not Proceed to Transplant
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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All Patients | Transplant Group | Canceled Group | p-Value | |
---|---|---|---|---|
Total patients, n | 872 | 494 | 378 | |
Age at referral, mean yrs (SD) | 54 (15.0) | 52 (14.8) | 58 (13.0) | <0.001 |
Sex (% male) | 61.9 | 61.5 | 62.1 | - |
Time intervals in transplant process, mean days (SD) | ||||
Referral to consult, mean days (SD) * | 35.8 (46.4) | 33.9 (49.0) | 35.1 (45.8) | 0.713 |
Consult to cancel, mean days (SD) * | - | - | 90.5 (131.3) | - |
Consult to transplant, mean days (SD) | - | 122 (93.5) | - | - |
Number of patients by disease, n (%) | ||||
Acute myeloid leukemia | 351 (40.3) | 214 (43.3) | 137 (36.2) | 0.03 |
Myelodysplastic syndrome | 200 (22.9) | 121 (24.5) | 79 (20.9) | 0.21 |
Acute lymphoblastic leukemia | 117 (13.4) | 78 (15.8) | 39 (10.3) | 0.02 |
Non-Hodgkin lymphoma | 47 (5.4) | 19 (3.8) | 28 (7.4) | 0.02 |
Myeloproliferative neoplasms | 41 (4.7) | 15 (3.0) | 26 (6.9) | 0.01 |
Chronic myeloid leukemia | 32 (3.7) | 12 (2.4) | 20 (5.3) | 0.03 |
Severe aplastic anemia | 25 (2.9) | 13 (2.6) | 12 (3.2) | 0.63 |
Chronic lymphocytic leukemia | 21 (2.4) | 9 (1.8) | 12 (3.2) | 0.20 |
Hodgkin lymphoma | 13 (1.5) | 5 (1.0) | 8 (2.1) | 0.18 |
Sickle cell anemia | 4 (0.5) | 2 (0.4) | 2 (0.5) | 0.79 |
Multiple myeloma | 4 (0.5) | 0 | 4 (1.1) | 0.02 |
Other | 17 (2.0) | 6 (1.2) | 11 (2.9) | 0.07 |
Donor Type | Number of Patients (%) |
---|---|
Matched unrelated | 317 (64.2%) |
Matched related | 96 (19.4%) |
Mismatch unrelated | 64 (13.0%) |
9/10 match | 63 (12.8%) |
8/10 match | 1 (0.2%) |
Haploidentical (related) | 15 (3.0%) |
Mismatch related (both 9/10) | 2 (0.4%) |
Indication for Cancellation | Number of Patients (%) |
---|---|
Disease-related | 203 (53.7) |
Patient preference | 61 (16.1) |
Patient comorbidity * | 45 (11.9) |
Patient deceased | 37 (9.9) |
Treatment toxicity ** | 13 (3.4) |
Donor unavailability *** | 11 (2.9) |
Transfer of care/Treatment at another centre | 6 (1.6) |
Other reason (not reported) | 2 (0.5) |
Patient Characteristic | % |
---|---|
Mean age, years (SD) (%) | 66.5 (9.2) |
Sex (% male) | 64% |
Number of patients by disease, n (%) | |
Acute myeloid leukemia | 4 (36%) |
Myelodysplastic syndrome | 3 (27%) |
Chronic myeloid leukemia | 2 (18%) |
Myelofibrosis with acute leukemia | 1 (9%) |
Living sibling(s) (≥1 alive), n (%) | 10 (91%) |
Sibling(s) (≥1) HLA typed | 4 (36%) |
Ethnicity of patient *, n (%) | |
Caucasian | 6 (55%) |
Native American | 2 (18%) |
African American | 1 (9%) |
Asian or Pacific Islander | 1 (9%) |
Loci not found/unable to assess | 1 (9%) |
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Monaghan, M.; Duong, A.; Abrol, K.; Doan, T.; Cieniak, C.; Atkins, H.; Kekre, N.; Masurekar, A.; Vasudevan Nampoothiri, R.; Thyagu, S.; et al. Real-World Selection of Patients for Allogeneic HCT at a Single Centre: Lack of a Suitable Donor and Other Reasons for Not Proceeding. Curr. Oncol. 2025, 32, 483. https://doi.org/10.3390/curroncol32090483
Monaghan M, Duong A, Abrol K, Doan T, Cieniak C, Atkins H, Kekre N, Masurekar A, Vasudevan Nampoothiri R, Thyagu S, et al. Real-World Selection of Patients for Allogeneic HCT at a Single Centre: Lack of a Suitable Donor and Other Reasons for Not Proceeding. Current Oncology. 2025; 32(9):483. https://doi.org/10.3390/curroncol32090483
Chicago/Turabian StyleMonaghan, Madeline, An Duong, Kalina Abrol, Trang Doan, Carolina Cieniak, Harold Atkins, Natasha Kekre, Ashish Masurekar, Ram Vasudevan Nampoothiri, Santhosh Thyagu, and et al. 2025. "Real-World Selection of Patients for Allogeneic HCT at a Single Centre: Lack of a Suitable Donor and Other Reasons for Not Proceeding" Current Oncology 32, no. 9: 483. https://doi.org/10.3390/curroncol32090483
APA StyleMonaghan, M., Duong, A., Abrol, K., Doan, T., Cieniak, C., Atkins, H., Kekre, N., Masurekar, A., Vasudevan Nampoothiri, R., Thyagu, S., Bredeson, C. N., Kennah, M., & Allan, D. S. (2025). Real-World Selection of Patients for Allogeneic HCT at a Single Centre: Lack of a Suitable Donor and Other Reasons for Not Proceeding. Current Oncology, 32(9), 483. https://doi.org/10.3390/curroncol32090483