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Communication

Osteolytic Bone Metastasis: Different Radiotherapy Fractionation Schedules Compared Clinically and Radiographically

1
Radiotherapy Unit, 1st Department of Radiology, Medical School, Aretaieion University Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece
2
Department of Clinical Radiation Oncology, Medical School, ΑΤΤΙΚΟΝ University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2024, 31(6), 3064-3072; https://doi.org/10.3390/curroncol31060233
Submission received: 26 April 2024 / Revised: 28 May 2024 / Accepted: 28 May 2024 / Published: 29 May 2024

Abstract

The purpose of this study is to compare three commonly used radiotherapy fractionation schedules for bone metastasis in terms of clinical and radiological effectiveness. A total of 93 patients with osteolytic bone metastasis were randomized to receive 8 Gyin a single fraction (group A), 20 Gy in 5 fractions (group B) and 30 Gy in 10 fractions (group C). Changes in bone density were measured using the Relative Electron Density (RED) type corrected by Thomas (pe = HU/1.950 +1.0), where HU is Hounsfield Units. Pain response was assessed according to the Brief Pain Inventory tool. Quality of life was estimated using the EORTC QLQ-C30 and the MD Anderson Symptom (MDAS) tools.After RT, RED, together with the parameters of EORTC QLQ-C30, MDAS and SAT, significantly increased in all groups (p<0.001).Specifically, the increase of RED was higher in group C compared to group Athree months post-RT (p=0.014). Group C was also superior to group A in terms of QoL and BPI three months post-treatment. Multifractionated radiotherapy for osteolytic bone metastasis is superior to single fraction radiotherapy in terms of improvement in quality of life and bone remineralization three months post-RT.
Keywords: osteolytic bone metastasis; radiotherapy; quality of life; bone density; remineralization osteolytic bone metastasis; radiotherapy; quality of life; bone density; remineralization

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MDPI and ACS Style

Liakouli, Z.; Zygogianni, A.; Georgakopoulos, I.; Mystakidou, K.; Kouvaris, J.; Antypas, C.; Nikoloudi, M.; Kouloulias, V. Osteolytic Bone Metastasis: Different Radiotherapy Fractionation Schedules Compared Clinically and Radiographically. Curr. Oncol. 2024, 31, 3064-3072. https://doi.org/10.3390/curroncol31060233

AMA Style

Liakouli Z, Zygogianni A, Georgakopoulos I, Mystakidou K, Kouvaris J, Antypas C, Nikoloudi M, Kouloulias V. Osteolytic Bone Metastasis: Different Radiotherapy Fractionation Schedules Compared Clinically and Radiographically. Current Oncology. 2024; 31(6):3064-3072. https://doi.org/10.3390/curroncol31060233

Chicago/Turabian Style

Liakouli, Zoi, Anna Zygogianni, Ioannis Georgakopoulos, Kyriaki Mystakidou, John Kouvaris, Christos Antypas, Maria Nikoloudi, and Vasileios Kouloulias. 2024. "Osteolytic Bone Metastasis: Different Radiotherapy Fractionation Schedules Compared Clinically and Radiographically" Current Oncology 31, no. 6: 3064-3072. https://doi.org/10.3390/curroncol31060233

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