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Current Oncology
Volume 30
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Article

Effect of Percutaneous Endoscopic Gastrostomy on Quality of Life after Chemoradiation for Locally Advanced Nasopharyngeal Carcinoma: A Cross-Sectional Study

by
Yun Xu
1,†,
Hewei Peng
2,†,
Qiaojuan Guo
1,3,
Lanyan Guo
4,
Xiane Peng
2,5,* and
Shaojun Lin
1,3,*
1
Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350000, China
2
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350000, China
3
Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou 350000, China
4
School of Medical Imaging, Fujian Medical University, Fuzhou 350000, China
5
Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou 350000, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Oncol. 2023, 30(1), 1000-1009; https://doi.org/10.3390/curroncol30010076
Submission received: 13 November 2022 / Revised: 25 December 2022 / Accepted: 3 January 2023 / Published: 10 January 2023
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Abstract

(1) Background: Prophylactic percutaneous endoscopic gastrostomy (PEG) maintained nutritional status and improved survival of patients with locally advanced nasopharyngeal carcinoma (LA-NPC). However, the role of PEG in patients’ quality of life (QoL) is still controversial. We aimed to investigate the effect of PEG on the QoL of patients with LA-NPC without progression. (2) Methods: Patients with LA-NPC between 1 June 2010 and 30 June 2014 in Fujian Cancer Hospital were divided into PEG and non-PEG groups. The QoL Questionnaire core 30 (QLQ-C30), incidence of adverse effects, weight, and xerostomia recovery were compared between the two groups of patients without progression as of 30 June 2020. (3) Results: No statistically significant difference in the scores of each QLQ-C30 scale between the two groups (p > 0.05). The incidence of xerostomia was higher in the PEG group than in the non-PEG group (p = 0.044), but the association was not seen after adjusting for gender, age, T, and N stage (OR: 0.902, 95%CI: 0.485–1.680). No significant difference in the incidence of other adverse effects as well as in weight and dry mouth recovery (p > 0.05). (4) Conclusion: PEG seems not to have a detrimental effect on long-term Qol, including the self-reported swallowing function of NPC patients without progressive disease.
Keywords: nasopharyngeal carcinoma; percutaneous endoscopic gastrostomy; intensity-modulated radiotherapy; nutritional support; quality of life nasopharyngeal carcinoma; percutaneous endoscopic gastrostomy; intensity-modulated radiotherapy; nutritional support; quality of life

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MDPI and ACS Style

Xu, Y.; Peng, H.; Guo, Q.; Guo, L.; Peng, X.; Lin, S. Effect of Percutaneous Endoscopic Gastrostomy on Quality of Life after Chemoradiation for Locally Advanced Nasopharyngeal Carcinoma: A Cross-Sectional Study. Curr. Oncol. 2023, 30, 1000-1009. https://doi.org/10.3390/curroncol30010076

AMA Style

Xu Y, Peng H, Guo Q, Guo L, Peng X, Lin S. Effect of Percutaneous Endoscopic Gastrostomy on Quality of Life after Chemoradiation for Locally Advanced Nasopharyngeal Carcinoma: A Cross-Sectional Study. Current Oncology. 2023; 30(1):1000-1009. https://doi.org/10.3390/curroncol30010076

Chicago/Turabian Style

Xu, Yun, Hewei Peng, Qiaojuan Guo, Lanyan Guo, Xiane Peng, and Shaojun Lin. 2023. "Effect of Percutaneous Endoscopic Gastrostomy on Quality of Life after Chemoradiation for Locally Advanced Nasopharyngeal Carcinoma: A Cross-Sectional Study" Current Oncology 30, no. 1: 1000-1009. https://doi.org/10.3390/curroncol30010076

APA Style

Xu, Y., Peng, H., Guo, Q., Guo, L., Peng, X., & Lin, S. (2023). Effect of Percutaneous Endoscopic Gastrostomy on Quality of Life after Chemoradiation for Locally Advanced Nasopharyngeal Carcinoma: A Cross-Sectional Study. Current Oncology, 30(1), 1000-1009. https://doi.org/10.3390/curroncol30010076

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