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Review

Exosomal Non-Coding RNAs: New Insights into the Biology of Hepatocellular Carcinoma

by 1, 1, 1, 2, 1,* and 1,3,4,*
1
School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China
2
School of Basic Medical Sciences, Chengdu University, Chengdu 610106, China
3
Central Nervous System Drug Key Laboratory of Sichuan Province, Luzhou 646000, China
4
Engineering, Informatics Fusion and Transformation Key Laboratory, Luzhou 646000, China
*
Authors to whom correspondence should be addressed.
Curr. Oncol. 2022, 29(8), 5383-5406; https://doi.org/10.3390/curroncol29080427
Received: 13 June 2022 / Revised: 26 July 2022 / Accepted: 27 July 2022 / Published: 29 July 2022
Exosomes, extracellular vesicles with a diameter of 40 to 160 nm, are among the smallest extracellular vesicles released by cells. They deliver different cargoes, including proteins, DNAs, and RNAs, and facilitate communication between cells to coordinate a variety of physiological and pathological functions. Hepatocellular carcinoma (HCC) is the sixth common malignant tumor and the fourth leading cause of cancer-related death worldwide. Its molecular mechanism remains largely unknown, and there is a lack of reliable and noninvasive biomarkers for early diagnosis and prognosis prediction. Mounting evidence has shown that exosomes carry a variety of ncRNAs, such as long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), which play critical roles in the occurrence and progression of HCC. In this review, we summarize the recent findings of exosomal miRNAs, lncRNAs, and circRNAs in HCC from their impact on the development of HCC to their potential applications in the diagnosis and treatment of HCC. View Full-Text
Keywords: exosome; hepatocellular carcinoma; long non-coding RNA; microRNA; tumor microenvironment exosome; hepatocellular carcinoma; long non-coding RNA; microRNA; tumor microenvironment
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MDPI and ACS Style

Zhang, Q.; Li, H.; Liu, Y.; Li, J.; Wu, C.; Tang, H. Exosomal Non-Coding RNAs: New Insights into the Biology of Hepatocellular Carcinoma. Curr. Oncol. 2022, 29, 5383-5406. https://doi.org/10.3390/curroncol29080427

AMA Style

Zhang Q, Li H, Liu Y, Li J, Wu C, Tang H. Exosomal Non-Coding RNAs: New Insights into the Biology of Hepatocellular Carcinoma. Current Oncology. 2022; 29(8):5383-5406. https://doi.org/10.3390/curroncol29080427

Chicago/Turabian Style

Zhang, Qian, Hanlin Li, Yang Liu, Jian Li, Chunling Wu, and Hua Tang. 2022. "Exosomal Non-Coding RNAs: New Insights into the Biology of Hepatocellular Carcinoma" Current Oncology 29, no. 8: 5383-5406. https://doi.org/10.3390/curroncol29080427

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