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Non-Alcoholic Fatty Liver Disease and Extrahepatic Cancers: A Wolf in Sheep’s Clothing?

Second Department of Surgery, University General Hospital of Alexandroupolis, Democritus University of Thrace Medical School, Dragana, 68100 Alexandroupolis, Greece
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Curr. Oncol. 2022, 29(7), 4478-4510; https://doi.org/10.3390/curroncol29070356
Received: 22 May 2022 / Revised: 23 June 2022 / Accepted: 23 June 2022 / Published: 25 June 2022
Non-alcoholic fatty liver disease (NAFLD) is now considered the main driver and leading cause of chronic liver disease globally. The umbrella term NAFLD describes a range of liver conditions closely related to insulin resistance, metabolic syndrome, diabetes mellitus, obesity, and dyslipidemia. At the same time, several malignancies, including hepatocellular carcinoma and colorectal cancer, are considered to be common causes of death among patients with NAFLD. At first, our review herein aims to investigate the role of NAFLD in developing colorectal neoplasms and adenomatous polyps based on the current literature. We will also explore the connection and the missing links between NAFLD and extrahepatic cancers. Interestingly, any relationship between NAFLD and extrahepatic malignancies could be attributable to several shared metabolic risk factors. Overall, obesity, insulin resistance, metabolic syndrome, and related disorders may increase the risk of developing cancer. Therefore, early diagnosis of NAFLD is essential for preventing the progression of the disease and avoiding its severe complications. In addition, cancer screening and early detection in these patients may improve survival and reduce any delays in treatment. View Full-Text
Keywords: non-alcoholic fatty liver disease; colorectal adenomas; colorectal cancer; extrahepatic cancers; metabolic syndrome; insulin resistance non-alcoholic fatty liver disease; colorectal adenomas; colorectal cancer; extrahepatic cancers; metabolic syndrome; insulin resistance
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MDPI and ACS Style

Mitsala, A.; Tsalikidis, C.; Romanidis, K.; Pitiakoudis, M. Non-Alcoholic Fatty Liver Disease and Extrahepatic Cancers: A Wolf in Sheep’s Clothing? Curr. Oncol. 2022, 29, 4478-4510. https://doi.org/10.3390/curroncol29070356

AMA Style

Mitsala A, Tsalikidis C, Romanidis K, Pitiakoudis M. Non-Alcoholic Fatty Liver Disease and Extrahepatic Cancers: A Wolf in Sheep’s Clothing? Current Oncology. 2022; 29(7):4478-4510. https://doi.org/10.3390/curroncol29070356

Chicago/Turabian Style

Mitsala, Athanasia, Christos Tsalikidis, Konstantinos Romanidis, and Michail Pitiakoudis. 2022. "Non-Alcoholic Fatty Liver Disease and Extrahepatic Cancers: A Wolf in Sheep’s Clothing?" Current Oncology 29, no. 7: 4478-4510. https://doi.org/10.3390/curroncol29070356

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