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Early-Age-Onset Colorectal Cancer in Canada: Evidence, Issues and Calls to Action

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Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
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Division of Medical Oncology, BC Cancer, University of British Columbia, Vancouver, BC V5Z 4E6, Canada
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Department of Surgery, University of Toronto, Toronto, ON M5T 1P5, Canada
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Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada
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Department of Surgery, University of Alberta, Edmonton, AB T5H 3V9, Canada
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Department of Community Health Sciences, University of Calgary, Calgary, AB T2N 4N1, Canada
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Department of Oncology, University of Calgary, Calgary, AB T2N 4N1, Canada
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Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, AB T2N 4N1, Canada
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Forzani & MacPhail Colon Cancer Screening Centre, Alberta Health Services, Calgary, AB T2N 4N1, Canada
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Division of Gastroenterology, University of Alberta, Edmonton, AB T6G 2X8, Canada
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Department of Psychiatry, University of Toronto, Toronto, ON M5T 1P5, Canada
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Division of Medical Oncology, Gastrointestinal Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
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Patient Advocate, Thornhill, ON L3T 3H1, Canada
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Colorectal Cancer Resource & Action Network, 700-2 Bloor Street West, Toronto, ON M4W 3E2, Canada
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Author to whom correspondence should be addressed.
Curr. Oncol. 2022, 29(5), 3149-3159; https://doi.org/10.3390/curroncol29050256
Received: 24 March 2022 / Revised: 25 April 2022 / Accepted: 27 April 2022 / Published: 29 April 2022
(This article belongs to the Section Gastrointestinal Oncology)
The inaugural Early-Age-Onset Colorectal Cancer Symposium was convened in June 2021 to discuss the implications of rapidly rising rates of early-age-onset colorectal cancer (EAO-CRC) in Canadians under the age of 50 and the impactful outcomes associated with this disease. While the incidence of CRC is declining in people over the age of 50 in Canada and other developed countries worldwide, it is significantly rising in younger people. Canadians born after 1980 are 2 to 2.5 times more likely to be diagnosed with CRC before the age of 50 than previous generations at the same age. While the etiology of EAO-CRC is largely unknown, its characteristics differ in many key ways from CRC diagnosed in older people and warrant a specific approach to risk factor identification, early detection and treatment. Participants of the symposium offered directions for research and clinical practice, and developed actionable recommendations to address the unique needs of these individuals diagnosed with EAO-CRC. Calls for action emerging from the symposium included: increased awareness of EAO-CRC among public and primary care practitioners; promotion of early detection programs in younger populations; and the continuation of research to identify unique risk factor profiles, tumour characteristics and treatment models that can inform tailored approaches to the management of EAO-CRC. View Full-Text
Keywords: early-age-onset colorectal cancer; EAO-CRC; EO-CRC; colorectal cancer early-age-onset colorectal cancer; EAO-CRC; EO-CRC; colorectal cancer
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MDPI and ACS Style

De Vera, M.A.; Gill, S.; Ashamalla, S.; Schiller, D.; Brenner, D.R.; Wong, C.; Wildgoose, P.; Esplen, M.J.; Lieu, C.; Fitzpatrick, R.; O’Sullivan, D.E.; Servidio-Italiano, F. Early-Age-Onset Colorectal Cancer in Canada: Evidence, Issues and Calls to Action. Curr. Oncol. 2022, 29, 3149-3159. https://doi.org/10.3390/curroncol29050256

AMA Style

De Vera MA, Gill S, Ashamalla S, Schiller D, Brenner DR, Wong C, Wildgoose P, Esplen MJ, Lieu C, Fitzpatrick R, O’Sullivan DE, Servidio-Italiano F. Early-Age-Onset Colorectal Cancer in Canada: Evidence, Issues and Calls to Action. Current Oncology. 2022; 29(5):3149-3159. https://doi.org/10.3390/curroncol29050256

Chicago/Turabian Style

De Vera, Mary A., Sharlene Gill, Shady Ashamalla, Dan Schiller, Darren R. Brenner, Clarence Wong, Petra Wildgoose, Mary Jane Esplen, Christopher Lieu, Roslyn Fitzpatrick, Dylan E. O’Sullivan, and Filomena Servidio-Italiano. 2022. "Early-Age-Onset Colorectal Cancer in Canada: Evidence, Issues and Calls to Action" Current Oncology 29, no. 5: 3149-3159. https://doi.org/10.3390/curroncol29050256

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