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Risk of Anxiety and Depression after Diagnosis of Young-Onset Colorectal Cancer: A Population-Based Cohort Study

1
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
2
Collaboration for Outcomes Research and Evaluation, Vancouver, BC V6T 1Z3, Canada
3
Arthritis Research Canada, Vancouver, BC V5Y 3P2, Canada
4
BC Cancer, Vancouver, BC V5Z 4E6, Canada
5
Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada
6
Centre for Health Evaluation and Outcome Sciences, Vancouver, BC V6Z IY6, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2022, 29(5), 3072-3081; https://doi.org/10.3390/curroncol29050249
Received: 24 March 2022 / Revised: 15 April 2022 / Accepted: 20 April 2022 / Published: 27 April 2022
Given the increasing incidence of young-onset colorectal cancer (yCRC; <50 years), we aimed to evaluate the risk of depression and anxiety in individuals with yCRC in comparison to average-age-onset CRC (aCRC; ≥50 years) and to cancer-free controls, with stratification by sex. Our cohort study identified individuals (≥18 years) with CRC and cancer-free controls (10:1) matched on age and sex using population-based linked administrative health databases in British Columbia, Canada. We assessed depression and anxiety using validated algorithms. We evaluated the risk of depression and anxiety using multivariable Cox proportional hazard models. The cohort included 54,634 individuals with CRC (46.5% female, mean age 67.9 years) and 546,340 controls (46.5% female, mean age 67.9 years). Those with yCRC as compared to aCRC had an increased risk for depression (adjusted hazard ratio [aHR] 1.41; 95% confidence interval [CI] 1.25 to 1.60), and when stratified by sex, the risk was only significant among males (aHR 1.76; 95% CI 1.48 to 2.10). When comparing individuals with yCRC to cancer-free controls, the overall risk of depression (aHR 1.00; 95% CI 0.92 to 1.10) and anxiety (aHR 1.10; 95% CI 0.95 to 1.27) was non-significant; however, males had a significantly higher risk for mental health disorders, specifically depression (aHR 1.17; 95% CI 1.03 to 1.33). Altogether, our findings that individuals with yCRC experience higher risk of depression compared to those with aCRC as well as cancer-free controls, particularly among males, suggest effects of age and sex on mental health outcomes. View Full-Text
Keywords: colorectal cancer; depression; anxiety colorectal cancer; depression; anxiety
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MDPI and ACS Style

Howren, A.; Sayre, E.C.; Cheng, V.; Oveisi, N.; McTaggart-Cowan, H.; Peacock, S.; De Vera, M.A. Risk of Anxiety and Depression after Diagnosis of Young-Onset Colorectal Cancer: A Population-Based Cohort Study. Curr. Oncol. 2022, 29, 3072-3081. https://doi.org/10.3390/curroncol29050249

AMA Style

Howren A, Sayre EC, Cheng V, Oveisi N, McTaggart-Cowan H, Peacock S, De Vera MA. Risk of Anxiety and Depression after Diagnosis of Young-Onset Colorectal Cancer: A Population-Based Cohort Study. Current Oncology. 2022; 29(5):3072-3081. https://doi.org/10.3390/curroncol29050249

Chicago/Turabian Style

Howren, Alyssa, Eric C. Sayre, Vicki Cheng, Niki Oveisi, Helen McTaggart-Cowan, Stuart Peacock, and Mary A. De Vera. 2022. "Risk of Anxiety and Depression after Diagnosis of Young-Onset Colorectal Cancer: A Population-Based Cohort Study" Current Oncology 29, no. 5: 3072-3081. https://doi.org/10.3390/curroncol29050249

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