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Current Oncology
Volume 29
Issue 5
10.3390/curroncol29050236
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Article

PIK3CA Mutation as Potential Poor Prognostic Marker in Asian Female Breast Cancer Patients Who Received Adjuvant Chemotherapy

by
Yoon Ah Cho
1,†,
Seung Yeon Ko
2,†,
Yong Joon Suh
3,
Sanghwa Kim
3,
Jung Ho Park
3,
Hye-Rim Park
1,
Jinwon Seo
1,
Hyo Geun Choi
4,
Ho Suk Kang
5,
Hyun Lim
5,
Ha Young Park
6 and
Mi Jung Kwon
1,*
1
Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea
2
Division of Breast and Endocrine Surgery, Catholic Kwandong University International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon 22711, Korea
3
Division of Breast and Endocrine Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea
4
Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea
5
Division of Gastroenterology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang 14068, Korea
6
Department of Pathology, Busan Paik Hospital, Inje University College of Medicine, Busan 48108, Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Oncol. 2022, 29(5), 2895-2908; https://doi.org/10.3390/curroncol29050236
Submission received: 13 March 2022 / Revised: 12 April 2022 / Accepted: 15 April 2022 / Published: 19 April 2022
(This article belongs to the Special Issue Personalized Care for Breast Cancer: Where Modern Technologies Meet an Integrated Approach to Diagnosis and Treatment Planning)
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Abstract

Background: The prognostic relevance of the PIK3CA mutation together with PD-L1, c-Met, and mismatch repair deficiency (dMMR) have not been fully investigated in Asian women with breast cancer (BC) who have undergone postoperative adjuvant chemotherapy. Methods: We analyzed PIK3CA mutations via peptide nucleic acid (PNA)-mediated real-time PCR assay, PD-L1/c-Met expression via immunohistochemistry (IHC), and microsatellite instability (MSI) status using PCR and IHC, in 191 resected BCs from 2008 to 2011. The Cancer Genome Atlas (TCGA) dataset for the involvement of the PIK3CA mutation with PD-L1/c-Met/MMR was explored. Results: The PNA clamp-mediated assay was able to detect the PIK3CA mutation in 1% of the mutant population in the cell line validation. Using this method, the PIK3CA mutation was found in 78 (49.4%) of 158 samples. c-Met and PD-L1 positivity were identified in 31.4 and 21.8% of samples, respectively, which commonly correlated with high histologic grade and triple-negative subtype. MSI/dMMR was observed in 8.4% of patients, with inconsistency between MMR IHC and the MSI PCR. The PIK3CA mutation exhibited a poor prognostic association regarding recurrence-free survival (RFS) in both overall and triple-negative BCs. In subgroup analyses, the PIK3CA-mutated tumors showed poorer RFS than the PIK3CA-wildtype within the c-Met-positive, MSS, triple-negative, or age onset <50 years subgroups, which showed a similar trend of association in TCGA data. Conclusions: PIK3CA mutation together with c-Met or dMMR/MSI status might be relevant to poor prognosis in BC subsets, especially in Asian women.
Keywords: PIK3CA mutation; adjuvant chemotherapy; breast cancer; invasive ductal carcinoma; c-Met; PD-L1; microsatellite instability; mismatch repair proteins PIK3CA mutation; adjuvant chemotherapy; breast cancer; invasive ductal carcinoma; c-Met; PD-L1; microsatellite instability; mismatch repair proteins
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MDPI and ACS Style

Cho, Y.A.; Ko, S.Y.; Suh, Y.J.; Kim, S.; Park, J.H.; Park, H.-R.; Seo, J.; Choi, H.G.; Kang, H.S.; Lim, H.; et al. PIK3CA Mutation as Potential Poor Prognostic Marker in Asian Female Breast Cancer Patients Who Received Adjuvant Chemotherapy. Curr. Oncol. 2022, 29, 2895-2908. https://doi.org/10.3390/curroncol29050236

AMA Style

Cho YA, Ko SY, Suh YJ, Kim S, Park JH, Park H-R, Seo J, Choi HG, Kang HS, Lim H, et al. PIK3CA Mutation as Potential Poor Prognostic Marker in Asian Female Breast Cancer Patients Who Received Adjuvant Chemotherapy. Current Oncology. 2022; 29(5):2895-2908. https://doi.org/10.3390/curroncol29050236

Chicago/Turabian Style

Cho, Yoon Ah, Seung Yeon Ko, Yong Joon Suh, Sanghwa Kim, Jung Ho Park, Hye-Rim Park, Jinwon Seo, Hyo Geun Choi, Ho Suk Kang, Hyun Lim, and et al. 2022. "PIK3CA Mutation as Potential Poor Prognostic Marker in Asian Female Breast Cancer Patients Who Received Adjuvant Chemotherapy" Current Oncology 29, no. 5: 2895-2908. https://doi.org/10.3390/curroncol29050236

APA Style

Cho, Y. A., Ko, S. Y., Suh, Y. J., Kim, S., Park, J. H., Park, H.-R., Seo, J., Choi, H. G., Kang, H. S., Lim, H., Park, H. Y., & Kwon, M. J. (2022). PIK3CA Mutation as Potential Poor Prognostic Marker in Asian Female Breast Cancer Patients Who Received Adjuvant Chemotherapy. Current Oncology, 29(5), 2895-2908. https://doi.org/10.3390/curroncol29050236

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