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Clinical Study of Sentinel Lymph Node Detection Using Photodynamic Eye for Abdominal Radical Trachelectomy

1
Department of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan
2
Department of Obstetrics and Gynecology, The Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan
3
Department of Pathology, Sasaki Foundation Kyoundo Hospital, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(6), 4709-4720; https://doi.org/10.3390/curroncol28060397
Received: 28 September 2021 / Revised: 1 November 2021 / Accepted: 13 November 2021 / Published: 15 November 2021
(This article belongs to the Section Gynecologic Oncology)
This study aimed to assess the accuracy of predicting pelvic lymph node status using sentinel lymph node (SLN) biopsy with indocyanine green (ICG) and to examine the outcomes of SLN biopsy-guided abdominal radical trachelectomy (ART). Patients with stage IA2–IB2 cervical cancer from January 2009 to January 2021 were included. ICG was injected before ART and SLNs were identified, excised, and assessed intraoperatively using fast-frozen sections. Systemic pelvic lymphadenectomy was subsequently performed. The SLN detection rate, sensitivity, and false-negative rate were determined. Thirty patients desiring fertility preservation were enrolled, of whom 26 successfully completed ART and four underwent radical hysterectomies because of metastatic primary SLNs. Bilateral SLNs were identified in all patients. The sensitivity, false-negative rate, and negative predictive value were 100%, 7.7%, and 92.3%, respectively. Three (12%) patients were lost to follow-up: two relapsed and one died of tumor progression. Of the nine patients who tried to conceive after surgery, four achieved pregnancy and three delivered healthy live infants. In women with early-stage cervical cancer who desired to conserve fertility, SLN mapping with ICG had a very high detection rate, sensitivity, and low false-negative rate. SLN biopsy-guided ART is a feasible and accurate method for assessing pelvic node status. View Full-Text
Keywords: sentinel lymph node; cervical cancer; abdominal radical trachelectomy; photodynamic eye; fertility sparing sentinel lymph node; cervical cancer; abdominal radical trachelectomy; photodynamic eye; fertility sparing
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MDPI and ACS Style

Harano, N.; Sakamoto, M.; Fukushima, S.; Iwai, S.; Koike, Y.; Horikawa, S.; Suzuki, K.; Narui, C.; Matsuoka, K.; Ozeki, R.; Iwaya, K.; Umayahara, K.; Tanaka, T.; Okamoto, A. Clinical Study of Sentinel Lymph Node Detection Using Photodynamic Eye for Abdominal Radical Trachelectomy. Curr. Oncol. 2021, 28, 4709-4720. https://doi.org/10.3390/curroncol28060397

AMA Style

Harano N, Sakamoto M, Fukushima S, Iwai S, Koike Y, Horikawa S, Suzuki K, Narui C, Matsuoka K, Ozeki R, Iwaya K, Umayahara K, Tanaka T, Okamoto A. Clinical Study of Sentinel Lymph Node Detection Using Photodynamic Eye for Abdominal Radical Trachelectomy. Current Oncology. 2021; 28(6):4709-4720. https://doi.org/10.3390/curroncol28060397

Chicago/Turabian Style

Harano, Naomi, Masaru Sakamoto, Souta Fukushima, Shinnosuke Iwai, Yuki Koike, Shingo Horikawa, Kayo Suzuki, Chikage Narui, Kazuko Matsuoka, Rinko Ozeki, Keiichi Iwaya, Kenji Umayahara, Tadao Tanaka, and Aikou Okamoto. 2021. "Clinical Study of Sentinel Lymph Node Detection Using Photodynamic Eye for Abdominal Radical Trachelectomy" Current Oncology 28, no. 6: 4709-4720. https://doi.org/10.3390/curroncol28060397

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