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Review

The Role of PET in Supratentorial and Infratentorial Pediatric Brain Tumors

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Nuclear Medicine Department, Ospedali Galliera, 16128 Genova, Italy
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AIMN Pediatric Study Group, 20159 Milan, Italy
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Department of Nuclear Medicine, University of Brescia and Spedali Civili Brescia, 25123 Brescia, Italy
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Unit of Nuclear Medicine, Fondazione Istituto G. Giglio, 90015 Cefalù, Italy
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Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and of Morpho-Functional Imaging, A.O.U. Policlinico G. Martino, University of Messina, 98125 Messina, Italy
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Department of Nuclear Medicine, University Hospital Zürich, 8091 Zürich, Switzerland
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Nuclear Medicine Unit, Ospedali Riuniti, Torrette di Ancona, 60126 Ancona, Italy
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Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, 00161 Rome, Italy
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Nuclear Medicine Unit, A.R.N.A.S. Ospedali Civico, Di Cristina e Benfratelli, 90127 Palermo, Italy
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(4), 2481-2495; https://doi.org/10.3390/curroncol28040226
Received: 18 May 2021 / Revised: 28 June 2021 / Accepted: 29 June 2021 / Published: 5 July 2021
Objective: This review aims to provide a summary of the clinical indications and limitations of PET imaging with different radiotracers, including 18F-fluorodeoxyglucose (18F-FDG) and other radiopharmaceuticals, in pediatric neuro-oncology, discussing both supratentorial and infratentorial tumors, based on recent literature (from 2010 to present). Methods: A literature search of the PubMed/MEDLINE database was carried out searching for articles on the use of PET in pediatric brain tumors. The search was updated until December 2020 and limited to original studies published in English after 1 January 2010. Results: 18F-FDG PET continues to be successfully employed in different settings in pediatric neuro-oncology, including diagnosis, grading and delineation of the target for stereotactic biopsy, estimation of prognosis, evaluation of recurrence, treatment planning and assessment of treatment response. Nevertheless, non-18F-FDG tracers, especially amino acid analogues seem to show a better performance in each clinical setting. Conclusions: PET imaging adds important information in the diagnostic work-up of pediatric brain tumors. International or national multicentric studies are encouraged in order to collect larger amount of data. View Full-Text
Keywords: positron emission tomography; brain tumors; pediatrics positron emission tomography; brain tumors; pediatrics
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MDPI and ACS Style

Cistaro, A.; Albano, D.; Alongi, P.; Laudicella, R.; Pizzuto, D.A.; Formica, G.; Romagnolo, C.; Stracuzzi, F.; Frantellizzi, V.; Piccardo, A.; Quartuccio, N. The Role of PET in Supratentorial and Infratentorial Pediatric Brain Tumors. Curr. Oncol. 2021, 28, 2481-2495. https://doi.org/10.3390/curroncol28040226

AMA Style

Cistaro A, Albano D, Alongi P, Laudicella R, Pizzuto DA, Formica G, Romagnolo C, Stracuzzi F, Frantellizzi V, Piccardo A, Quartuccio N. The Role of PET in Supratentorial and Infratentorial Pediatric Brain Tumors. Current Oncology. 2021; 28(4):2481-2495. https://doi.org/10.3390/curroncol28040226

Chicago/Turabian Style

Cistaro, Angelina, Domenico Albano, Pierpaolo Alongi, Riccardo Laudicella, Daniele A. Pizzuto, Giuseppe Formica, Cinzia Romagnolo, Federica Stracuzzi, Viviana Frantellizzi, Arnoldo Piccardo, and Natale Quartuccio. 2021. "The Role of PET in Supratentorial and Infratentorial Pediatric Brain Tumors" Current Oncology 28, no. 4: 2481-2495. https://doi.org/10.3390/curroncol28040226

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