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Possible Therapeutic Potential of Disulfiram for Multiple Myeloma

1
Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University, 77900 Olomouc, Czech Republic
2
Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 77900 Olomouc, Czech Republic
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(3), 2087-2096; https://doi.org/10.3390/curroncol28030193
Received: 29 April 2021 / Revised: 22 May 2021 / Accepted: 1 June 2021 / Published: 3 June 2021
(This article belongs to the Section Medical Oncology)
Multiple myeloma (MM) is a malignant disease of the plasma cells representing approximately 10% of all hemato-oncological diseases. Detection of the disease is most probable at around 65 years of age, and the average survival of patients is estimated to be 5–10 years, specifically due to frequent relapses and resistance to the therapy used. Thus, the search for new therapeutic approaches is becoming a big challenge. Disulfiram (DSF), a substance primarily known as a medication against alcoholism, has often been mentioned in recent years in relation to cancer treatment for its secondary anti-cancer effects. Recent studies performed on myeloma cell lines confirm high inhibition of the cell growth activity if a complex of disulfiram and copper is used. Its significant potential is now being seen in the cure of haematological malignities. View Full-Text
Keywords: multiple myeloma; disulfiram; relapses; pharmacoresistant; therapy multiple myeloma; disulfiram; relapses; pharmacoresistant; therapy
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MDPI and ACS Style

Weiser Drozdkova, D.; Smesny Trtkova, K. Possible Therapeutic Potential of Disulfiram for Multiple Myeloma. Curr. Oncol. 2021, 28, 2087-2096. https://doi.org/10.3390/curroncol28030193

AMA Style

Weiser Drozdkova D, Smesny Trtkova K. Possible Therapeutic Potential of Disulfiram for Multiple Myeloma. Current Oncology. 2021; 28(3):2087-2096. https://doi.org/10.3390/curroncol28030193

Chicago/Turabian Style

Weiser Drozdkova, Denisa; Smesny Trtkova, Katerina. 2021. "Possible Therapeutic Potential of Disulfiram for Multiple Myeloma" Curr. Oncol. 28, no. 3: 2087-2096. https://doi.org/10.3390/curroncol28030193

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