Next Article in Journal
Testing Mayo Clinic’s New 20/20/20 Risk Model in Another Cohort of Smoldering Myeloma Patients: A Retrospective Study
Previous Article in Journal
Ethical Considerations in Chemotherapy and Vaccines in Cancer Patients in Times of the COVID-19 Pandemic
Article

Results from a Theory-Guided Survey to Support Breast Cancer Trial Participation: Barriers, Enablers, and What to Do about them

1
Clinical Epidemiology Program, Ottawa Hospital Research Institute (OHRI), The Ottawa Hospital, General Campus, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada
2
School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON K1G 5Z3, Canada
3
Canadian Breast Cancer Network, 331 Cooper St. Suite 602, Ottawa, ON K2P 0G5, Canada
4
Clinical Trials Ontario, 661 University Avenue, Suite 460, MaRS Centre, West Tower, Toronto, ON M5G 1M1, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2021, 28(3), 2014-2028; https://doi.org/10.3390/curroncol28030187
Received: 23 March 2021 / Revised: 18 May 2021 / Accepted: 21 May 2021 / Published: 26 May 2021
Background: Ensuring adequate, informed, and timely participation in clinical trials is a multifactorial problem. We have previously developed a systematic, tailorable survey development approach that is informed by theory, can identify barriers and enablers to participation, and can suggest recruitment strategies to address these issues. In this study, we surveyed subscribers to the Canadian Breast Cancer Network (CBCN) in order to identify a comprehensive list of theory-informed barriers and enablers relevant to participation in a hypothetical breast cancer trial. Methods: We developed and conducted an online survey of breast cancer patients informed by the Theoretical Domains Framework and designed to determine previous experience with clinical trials, knowledge about clinical trials, and importance of a comprehensive list of barriers and enablers to trial participation. Participants were contacted by email or through social media. Results: From 2451 subscribers of the CBCN, we received 244 responses and 210 completed surveys (244/2451 or 9.9% participation, 210/244 or 86.1% completion). A total of 38% of respondents indicated experience in trial participation, but 83% indicated confidence in their knowledge about clinical trials. Those who had previously participated in clinical trials were more confident in their knowledge (χ2= 6.77, p = 0.009) and answered more knowledge questions (t = −3.90 p = 0.000). Endorsed barriers and enablers to participation included 39 factors across 12 of 14 domains relevant to behaviour change. Our approach identifies barriers that might be meaningfully addressed by careful knowledge provision (‘If I would learn more about my condition’; ‘If I find the trial documents hard to understand’), those that may require other theory-informed approaches to address (‘my feelings about the quality of my drug plan’; ‘my worry over unknown side effects’), and those that may require tailored approaches depending on participant differences such as previous experience in trials (‘If there were patient-friendly decision-making tools to help you make your participation decision’). Discussion: This work demonstrates that a comprehensive, theory-guided survey of barriers and enablers to participation in breast cancer clinical trials is feasible, can lead to detailed knowledge about the issues related to participation in specific trials, and most importantly, can lead to insights about evidence-based ways to better support patient participation. View Full-Text
Keywords: trial participation; recruitment; survey; breast cancer; theory; theoretical domains; barriers and drivers to participation trial participation; recruitment; survey; breast cancer; theory; theoretical domains; barriers and drivers to participation
Show Figures

Figure 1

MDPI and ACS Style

Brehaut, J.C.; Carroll, K.; Gordon, J.; Presseau, J.; Richards, D.P.; Fergusson, D.A.; Graham, I.D.; Marlin, S. Results from a Theory-Guided Survey to Support Breast Cancer Trial Participation: Barriers, Enablers, and What to Do about them. Curr. Oncol. 2021, 28, 2014-2028. https://doi.org/10.3390/curroncol28030187

AMA Style

Brehaut JC, Carroll K, Gordon J, Presseau J, Richards DP, Fergusson DA, Graham ID, Marlin S. Results from a Theory-Guided Survey to Support Breast Cancer Trial Participation: Barriers, Enablers, and What to Do about them. Current Oncology. 2021; 28(3):2014-2028. https://doi.org/10.3390/curroncol28030187

Chicago/Turabian Style

Brehaut, Jamie C.; Carroll, Kelly; Gordon, Jenn; Presseau, Justin; Richards, Dawn P.; Fergusson, Dean A.; Graham, Ian D.; Marlin, Susan. 2021. "Results from a Theory-Guided Survey to Support Breast Cancer Trial Participation: Barriers, Enablers, and What to Do about them" Curr. Oncol. 28, no. 3: 2014-2028. https://doi.org/10.3390/curroncol28030187

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop