Next Article in Journal
Body Composition as a Predictor of Toxicity and Prognosis in Patients with Diffuse Large B-Cell Lymphoma Receiving R-CHOP Immunochemotherapy
Previous Article in Journal
The Role of Denosumab for Surgical Outcomes in Patients with Giant Cell Tumour of Bone: A Systematic Review
Open AccessArticle

Clinicopathological Significances of Tumor–Stroma Ratio (TSR) in Colorectal Cancers: Prognostic Implication of TSR Compared to Hypoxia-Inducible Factor-1α Expression and Microvessel Density

by 1,†, 2,†, 3 and 4,5,*
1
Department of Pathology, Daehang Hospital, Seoul 06699, Korea
2
Department of Pathology, Uijeongbu Eulji University Hospital, Eulji University School of Medicine, Gyeonggi Province, Kyeonggi-Do 11759, Korea
3
Department of Internal Medicine, Daejeon Eulji University Hospital, Eulji University School of Medicine, Daejeon 35233, Korea
4
Department of Pathology, Chungnam National University Sejong Hospital, 20 Bodeum 7-Ro, Sejong 30099, Korea
5
Department of Pathology, Chungnam National University School of Medicine, 266 Munhwa Street, Daejeon 35015, Korea
*
Author to whom correspondence should be addressed.
Guhyun Kang and Jung-Soo Pyo have contributed equally to this study.
Curr. Oncol. 2021, 28(2), 1314-1324; https://doi.org/10.3390/curroncol28020125
Received: 9 February 2021 / Revised: 10 March 2021 / Accepted: 18 March 2021 / Published: 22 March 2021
(This article belongs to the Section Gastrointestinal Oncology)
The present study aimed to elucidate the clinicopathological significance and prognostic implications of tumor–stroma ratio (TSR) in colorectal cancers (CRCs). TSRs were investigated in 266 human CRC specimens. The correlations between TSR and clinicopathological characteristics and survival were evaluated. The hypoxia-inducible factor-1α (HIF-1α) immunohistochemical expression of tumor cells and microvessel density (MVD) of stroma were compared between stroma-low and stroma-high subgroups. Results: Stroma-low was found in 185 of 266 CRCs (69.5%). Stroma-low was significantly correlated with less frequent vascular and perineural invasion and distant metastasis than stroma-high. HIF-1α of tumor cells was more highly expressed in the stroma-high subgroup than in the stroma-low subgroup. In addition, MVD was significantly higher in the stroma-high subgroup compared to the stroma-low subgroup. The stroma-low rate was increased considerably in CRCs with a mucinous component and decreased in CRCs with a micropapillary component. There were significant correlations between stroma-low and better overall and recurrence-free survivals. Similar to the literature, we observed that stroma-low was significantly correlated with favorable tumor behaviors and better survival. The microscopic examination of TSR can be useful for predicting the prognosis of CRC patients. View Full-Text
Keywords: tumor–stroma ratio; colorectal cancers; clinicopathological significance; hypoxia-inducible factor-1; microvessel density tumor–stroma ratio; colorectal cancers; clinicopathological significance; hypoxia-inducible factor-1; microvessel density
Show Figures

Figure 1

MDPI and ACS Style

Kang, G.; Pyo, J.-S.; Kim, N.-Y.; Kang, D.-W. Clinicopathological Significances of Tumor–Stroma Ratio (TSR) in Colorectal Cancers: Prognostic Implication of TSR Compared to Hypoxia-Inducible Factor-1α Expression and Microvessel Density. Curr. Oncol. 2021, 28, 1314-1324. https://doi.org/10.3390/curroncol28020125

AMA Style

Kang G, Pyo J-S, Kim N-Y, Kang D-W. Clinicopathological Significances of Tumor–Stroma Ratio (TSR) in Colorectal Cancers: Prognostic Implication of TSR Compared to Hypoxia-Inducible Factor-1α Expression and Microvessel Density. Current Oncology. 2021; 28(2):1314-1324. https://doi.org/10.3390/curroncol28020125

Chicago/Turabian Style

Kang, Guhyun; Pyo, Jung-Soo; Kim, Nae-Yu; Kang, Dong-Wook. 2021. "Clinicopathological Significances of Tumor–Stroma Ratio (TSR) in Colorectal Cancers: Prognostic Implication of TSR Compared to Hypoxia-Inducible Factor-1α Expression and Microvessel Density" Curr. Oncol. 28, no. 2: 1314-1324. https://doi.org/10.3390/curroncol28020125

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop