Next Article in Journal
The Influence of Gene Aberrations on Survival in Resected IDH Wildtype Glioblastoma Patients: A Single-Institution Study
Previous Article in Journal
Comparison of Perioperative Chemotherapy versus Postoperative Chemoradiotherapy for Operable Stomach Cancer: A Western Canadian Province Experience
Open AccessCase Report

PTEN R130Q Papillary Tumor of the Pineal Region (PTPR) with Chromosome 10 Loss Successfully Treated with Everolimus: A Case Report

1
Division of Hematology & Oncology, Naef K. Basile Cancer Institute, American University of Beirut Medical Center, Cairo Street, Beirut P.O. Box 11-0236, Lebanon
2
Faculty of Medicine, American University of Beirut, Bliss Street, Beirut P.O. Box 11-0236, Lebanon
3
Division of Neurosurgery, Lebanese American University Medical Center, Beirut P.O. Box 11-3288, Lebanon
4
Division of Radiation Oncology, American University of Beirut Medical Center, Cairo Street, Beirut P.O. Box 11-0236, Lebanon
5
Division of Diagnostic Radiology, American University of Beirut Medical Center, Bliss Street, Beirut P.O. Box 11-0236, Lebanon
6
Department of Internal Medicine, American University of Beirut Medical Center, Cairo Street, Beirut P.O. Box 11-0236, Lebanon
7
Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Cairo Street, Beirut P.O. Box 11-0236, Lebanon
8
Division of Neurosurgery, American University of Beirut Medical Center, Cairo Street, Beirut P.O. Box 11-0236, Lebanon
9
Department of Pediatric Neurology, Faculty of Medicine, Lebanese University, Beirut P.O. Box 6573/14, Lebanon
*
Author to whom correspondence should be addressed.
Both authors contributed equally to this paper.
Curr. Oncol. 2021, 28(2), 1274-1279; https://doi.org/10.3390/curroncol28020121
Received: 21 December 2020 / Revised: 7 February 2021 / Accepted: 19 February 2021 / Published: 20 March 2021
Papillary tumors of the pineal region (PTPR) can be observed among adults with poor prognosis and high recurrence rates. Standards of therapy involve total surgical excision along with radiation therapy, with no promising prospects for primary adjuvant chemotherapy, as long-term treatment options have not been explored. Chromosome 10 loss is characteristic of PTPR, and PTEN gene alterations are frequently encountered in a wide range of human cancers and may be treated with mTORC1 inhibitors such as everolimus. In parallel, there are no reports of treating PTPR with everolimus alone as a monopharmacotherapy. We report the case of a patient diagnosed with PTPR (grade III) characterized by a PTEN R130Q alteration with chromosome 10 loss that was treated with everolimus pharmacotherapy alone, resulting in an asymptomatic course and tumor regression, a rare yet notable phenomenon not described in the literature so far with potential to alter the management approach to patients with PTPR. View Full-Text
Keywords: papillary tumors of the pineal region; pineal parenchymal tumor; everolimus; PTEN; case report papillary tumors of the pineal region; pineal parenchymal tumor; everolimus; PTEN; case report
Show Figures

Graphical abstract

MDPI and ACS Style

Assi, H.I.; Kakati, R.T.; Berro, J.; Saikali, I.; Youssef, B.; Hourany, R.; Alameh, I.; Tabbarah, A.; Khoury, J.; Darwish, H.; Alame, S. PTEN R130Q Papillary Tumor of the Pineal Region (PTPR) with Chromosome 10 Loss Successfully Treated with Everolimus: A Case Report. Curr. Oncol. 2021, 28, 1274-1279. https://doi.org/10.3390/curroncol28020121

AMA Style

Assi HI, Kakati RT, Berro J, Saikali I, Youssef B, Hourany R, Alameh I, Tabbarah A, Khoury J, Darwish H, Alame S. PTEN R130Q Papillary Tumor of the Pineal Region (PTPR) with Chromosome 10 Loss Successfully Treated with Everolimus: A Case Report. Current Oncology. 2021; 28(2):1274-1279. https://doi.org/10.3390/curroncol28020121

Chicago/Turabian Style

Assi, Hazem I.; Kakati, Rasha T.; Berro, Juliett; Saikali, Ibrahim; Youssef, Bassem; Hourany, Roula; Alameh, Ibrahim; Tabbarah, Abeer; Khoury, Jessica; Darwish, Houssein; Alame, Saada. 2021. "PTEN R130Q Papillary Tumor of the Pineal Region (PTPR) with Chromosome 10 Loss Successfully Treated with Everolimus: A Case Report" Curr. Oncol. 28, no. 2: 1274-1279. https://doi.org/10.3390/curroncol28020121

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop