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Current Oncology
Volume 27
Issue 6
10.3747/co.27.6919
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Article

Canadian Guidelines on the Management of Colorectal Peritoneal Metastases

by
A. Brind’Amour
1,2,
P. Dubé
1,3,
J.F. Tremblay
1,3,
M.L. Soucisse
1,3,
L. Mack
4,
A. Bouchard-Fortier
4,
J.A. McCart
5,6,
A. Govindarajan
5,6,
D. Bischof
5,6,
E. Haase
7,
C. Giacomantonio
8,
P. Hebbard
9,
R. Younan
3,10,
A MacNeill
11,
C. Boulanger-Gobeil
2 and
Lucas Sidéris
1,3,*
1
Department of Surgery, Hôpital Maisonneuve-Rosemont, Montreal, QC H1T 2M4, Canada
2
Department of Surgery, CHU de Québec-Université Laval, Quebec City, QC, Canada
3
Department of Surgery, University of Montreal, Montreal, QC, Canada
4
Department of Surgery, University of Calgary, Calgary, AB, Canada
5
Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
6
Department of Surgery, University of Toronto, Toronto, ON, Canada
7
Department of Surgery, University of Alberta, Edmonton, AB, Canada
8
Department of Surgery, Dalhousie University, Halifax, NS, Canada
9
Department of Surgery, University of Manitoba, Winnipeg, MB, Canada
10
Department of Surgery, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada
11
Department of Surgery, University of British Columbia, Vancouver, BC, Canada
 
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Author to whom correspondence should be addressed.
Curr. Oncol. 2020, 27(6), 621-631; https://doi.org/10.3747/co.27.6919
Submission received: 5 September 2020 / Revised: 3 October 2020 / Accepted: 7 November 2020 / Published: 1 December 2020

Abstract

Modern management of colorectal cancer (CRC) with peritoneal metastasis (PM) is based on a combination of cytoreductive surgery (CRS), systemic chemotherapy, and hyperthermic intraperitoneal chemotherapy (HIPEC). Although the role of hipec has recently been questioned with respect to results from the PRODIGE 7 trial, the role and benefit of a complete CRS were confirmed, as observed with a 41-month gain in median survival in that study, and 15% of patients remaining disease-free at 5 years. Still, CRC with PM is associated with a poor prognosis, and good patient selection is essential. Many questions about the optimal management approach for such patients remain, but all patients with PM from CRC should be referred to, or discussed with, a PM surgical oncologist, because cure is possible. The objective of the present guideline is to offer a practical approach to the management of PM from CRC and to reflect on the new practice standards set by recent publications on the topic.
Keywords: peritoneal metastases; colorectal cancer; cytoreductive surgery; hyperthermic intraperitoneal chemotherapy; peritoneal carcinomatosis peritoneal metastases; colorectal cancer; cytoreductive surgery; hyperthermic intraperitoneal chemotherapy; peritoneal carcinomatosis

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MDPI and ACS Style

Brind’Amour, A.; Dubé, P.; Tremblay, J.F.; Soucisse, M.L.; Mack, L.; Bouchard-Fortier, A.; McCart, J.A.; Govindarajan, A.; Bischof, D.; Haase, E.; et al. Canadian Guidelines on the Management of Colorectal Peritoneal Metastases. Curr. Oncol. 2020, 27, 621-631. https://doi.org/10.3747/co.27.6919

AMA Style

Brind’Amour A, Dubé P, Tremblay JF, Soucisse ML, Mack L, Bouchard-Fortier A, McCart JA, Govindarajan A, Bischof D, Haase E, et al. Canadian Guidelines on the Management of Colorectal Peritoneal Metastases. Current Oncology. 2020; 27(6):621-631. https://doi.org/10.3747/co.27.6919

Chicago/Turabian Style

Brind’Amour, A., P. Dubé, J.F. Tremblay, M.L. Soucisse, L. Mack, A. Bouchard-Fortier, J.A. McCart, A. Govindarajan, D. Bischof, E. Haase, and et al. 2020. "Canadian Guidelines on the Management of Colorectal Peritoneal Metastases" Current Oncology 27, no. 6: 621-631. https://doi.org/10.3747/co.27.6919

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