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Current Oncology
Volume 26
Issue 6
10.3747/co.26.5185
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Neoadjuvant Radiotherapy Followed by Surgery Compared with Surgery Alone in the Treatment of Retroperitoneal SarcomA: A Population-Based Comparison

by
B. T. Turner
1,
L. Hampton
2,
D. Schiller
3,
L. A. Mack
1,
C. Robertson-More
4,
H. Li
5,
M. L. Quan
1,5 and
Antoine Bouchard-Fortier
1,*
1
Division of General Surgery, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada
2
Cumming School of Medicine, Calgary, AB, Canada
3
Department of Surgery, Royal Alexandra Hospital, Edmonton, AB, Canada
4
General Surgery Residency Program, University of Calgary, Calgary, AB, Canada
5
Departments of Oncology and Community Health Sciences, University of Calgary, Calgary, AB, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2019, 26(6), 766-772; https://doi.org/10.3747/co.26.5185
Submission received: 10 September 2019 / Revised: 6 October 2019 / Accepted: 4 November 2019 / Published: 1 December 2019

Abstract

Introduction: Retroperitoneal sarcoma (rps) encompasses a heterogeneous group of malignancies with a high recurrence rate after resection. Neoadjuvant radiotherapy (nrt) is often used in the hope of sterilizing margins and decreasing local recurrence after excision. We set out to compare local recurrence-free survival (lrfs) and overall survival (os) in patients treated with or without nrt before resection. Methods: Patients diagnosed with rps from February 1990 to October 2014 were identified in the Alberta Cancer Registry. Patients with complete gross resection of rps and no distant disease were included. Patient, tumour, treatment, and outcomes data were abstracted in a primary chart review. Baseline characteristics were compared using the Wilcoxon nonparametric test for continuous data and the Fisher exact test for dichotomous and categorical data. Survival was analyzed using Kaplan–Meier curves with log-rank test. Cox regression was performed to control for age, sex, tumour size, tumour grade, date of diagnosis, multivisceral resection, and intraoperative rupture. Results: Resection alone was performed in 62 patients, and resection after nrt, in 40. Use of nrt was associated with multivisceral resection and negative microscopic margins. On univariate analysis, nrt was associated with superior median lrfs (89.3 months vs. 28.4 months, p = 0.04) and os (119.4 months vs. 75.9 months, p = 0.04). On multivariate analysis, nrt, younger age, and lower tumour grade predicted improved lrfs and os; sex, tumour size, date of diagnosis, multivisceral resection, and tumour rupture did not. Conclusions: In this population-based study, nrt was associated with superior lrfs and os on both univariate and multivariate analysis. When feasible, nrt should be considered until a randomized controlled trial is completed.
Keywords: Sarcoma; radiotherapy Sarcoma; radiotherapy

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MDPI and ACS Style

Turner, B.T.; Hampton, L.; Schiller, D.; Mack, L.A.; Robertson-More, C.; Li, H.; Quan, M.L.; Bouchard-Fortier, A. Neoadjuvant Radiotherapy Followed by Surgery Compared with Surgery Alone in the Treatment of Retroperitoneal SarcomA: A Population-Based Comparison. Curr. Oncol. 2019, 26, 766-772. https://doi.org/10.3747/co.26.5185

AMA Style

Turner BT, Hampton L, Schiller D, Mack LA, Robertson-More C, Li H, Quan ML, Bouchard-Fortier A. Neoadjuvant Radiotherapy Followed by Surgery Compared with Surgery Alone in the Treatment of Retroperitoneal SarcomA: A Population-Based Comparison. Current Oncology. 2019; 26(6):766-772. https://doi.org/10.3747/co.26.5185

Chicago/Turabian Style

Turner, B. T., L. Hampton, D. Schiller, L. A. Mack, C. Robertson-More, H. Li, M. L. Quan, and Antoine Bouchard-Fortier. 2019. "Neoadjuvant Radiotherapy Followed by Surgery Compared with Surgery Alone in the Treatment of Retroperitoneal SarcomA: A Population-Based Comparison" Current Oncology 26, no. 6: 766-772. https://doi.org/10.3747/co.26.5185

APA Style

Turner, B. T., Hampton, L., Schiller, D., Mack, L. A., Robertson-More, C., Li, H., Quan, M. L., & Bouchard-Fortier, A. (2019). Neoadjuvant Radiotherapy Followed by Surgery Compared with Surgery Alone in the Treatment of Retroperitoneal SarcomA: A Population-Based Comparison. Current Oncology, 26(6), 766-772. https://doi.org/10.3747/co.26.5185

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