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Current Oncology
Volume 26
Issue 2
10.3747/co.26.4471
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Clinical Significance of Epithelial–Mesenchymal Transition–Related Molecules in Lung Adenocarcinoma

by
Y. Zhang
1,
L.F. Wang
1,
J.H. Gao
2,
L. Li
3,
P. Jiang
1,
X. Lv
1,
L.X. Yu
1,
J. Yang
3,
R.T. Li
1,* and
B.R. Liu
1
1
The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University, and Clinical Cancer Institute of Nanjing University, Nanjing, China
2
The Comprehensive Cancer Center, Suzhou Yongding Hospital, Suzhou, China
3
Department of Pathology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2019, 26(2), 121-127; https://doi.org/10.3747/co.26.4471
Submission received: 5 January 2019 / Revised: 5 February 2019 / Accepted: 5 March 2019 / Published: 1 April 2019

Abstract

Background: Epithelial–mesenchymal transition (EMT) refers to the biologic process in which epithelial cells are transformed into interstitial phenotypes by specific pathways. This transition plays an important biologic role in the process by which epithelium-derived malignant tumour cells acquire the ability to migrate and invade. We explored the relationship between EMT-associated molecules and patient-related clinical factors to determine whether any clinical characteristics could be used as biomarkers for EMT-related protein alterations in lung cancer—especially lung adenocarcinoma. Methods: Tumour specimens were collected from 80 patients with lung adenocarcinoma who underwent surgery or lung biopsy, with 4 patients being evaluated a 2nd time after re-biopsy. Expression of EMT-related proteins, including E-cadherin and vimentin, was evaluated by immunohistochemistry. We analyzed the relationship between clinicopathologic characteristics and expression level of the EMT markers. Results: Positive expression of E-cadherin was observed in 63 patients (79%), and vimentin, in 46 patients (57.5%). No significant relationships between E-cadherin or vimentin expression and smoking history, sex, age, driving gene mutations, or cell differentiation were identified. A significant correlation was observed between vimentin expression and pathologic stage. Of the 4 patients who were evaluated a 2nd time after re-biopsy, 3 showed the same emt-related protein expression status as in the first analysis. In the remaining patient, E-cadherin had changed completely. Conclusions: Clinicopathologic factors in cancer patients did not help to diagnose emt status in lung adenocarcinoma; however, TNM stage might be associated with vimentin expression.
Keywords: epithelial–mesenchymal transition; lung adenocarcinoma; E-cadherin; vimentin; clinicopathologic factors epithelial–mesenchymal transition; lung adenocarcinoma; E-cadherin; vimentin; clinicopathologic factors

Share and Cite

MDPI and ACS Style

Zhang, Y.; Wang, L.F.; Gao, J.H.; Li, L.; Jiang, P.; Lv, X.; Yu, L.X.; Yang, J.; Li, R.T.; Liu, B.R. Clinical Significance of Epithelial–Mesenchymal Transition–Related Molecules in Lung Adenocarcinoma. Curr. Oncol. 2019, 26, 121-127. https://doi.org/10.3747/co.26.4471

AMA Style

Zhang Y, Wang LF, Gao JH, Li L, Jiang P, Lv X, Yu LX, Yang J, Li RT, Liu BR. Clinical Significance of Epithelial–Mesenchymal Transition–Related Molecules in Lung Adenocarcinoma. Current Oncology. 2019; 26(2):121-127. https://doi.org/10.3747/co.26.4471

Chicago/Turabian Style

Zhang, Y., L.F. Wang, J.H. Gao, L. Li, P. Jiang, X. Lv, L.X. Yu, J. Yang, R.T. Li, and B.R. Liu. 2019. "Clinical Significance of Epithelial–Mesenchymal Transition–Related Molecules in Lung Adenocarcinoma" Current Oncology 26, no. 2: 121-127. https://doi.org/10.3747/co.26.4471

APA Style

Zhang, Y., Wang, L. F., Gao, J. H., Li, L., Jiang, P., Lv, X., Yu, L. X., Yang, J., Li, R. T., & Liu, B. R. (2019). Clinical Significance of Epithelial–Mesenchymal Transition–Related Molecules in Lung Adenocarcinoma. Current Oncology, 26(2), 121-127. https://doi.org/10.3747/co.26.4471

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