Next Article in Journal
Lessons Learned Implementing a Province-Wide Smoking Cessation Initiative in Ontario’s Cancer Centres
Previous Article in Journal
Physician "Out of Office" Alert: Does It Work?
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Current Oncology
Volume 24
Issue 3
10.3747/co.24.3348
curroncol-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Diagnostic Value of Epidermal Growth Factor, Cancer Antigen 125, and Cancer Antigen 15-3 in Bronchoalveolar Lavage Fluid of Lung Cancer

by
S. Sun
1,
Z. Chen
2,
Chao Cao
3,*,
B. Wu
4,
B. Wang
1,
Y. Yu
1,
Z. Chen
1,
Z. Hu
5 and
Zaichun Deng
1,*
1
Department of Respiratory Medicine, The Affiliated Hospital of Medical College, Ningbo University, 247 Renmin Road, Jiangbei District, Ningbo, Zhejiang, China
2
Department of Emergency Medicine, Ningbo First Hospital, Ningbo, Zhejiang, China
3
Department of Respiratory Medicine, Ningbo First Hospital, 59 Liuting Street, Haishu District, Ningbo, Zhejiang, China
4
Department of Respiratory and Critical Care Medicine, Affiliated Hospital, Institute of Respiratory Diseases, Guangdong Medicine College, Zhanjiang, Guangdong, China
5
Department of Respiratory Medicine, Cixi People's Hospital, Cixi, Zhejiang, China
*
Authors to whom correspondence should be addressed.
Curr. Oncol. 2017, 24(3), 180-184; https://doi.org/10.3747/co.24.3348
Submission received: 4 March 2017 / Revised: 5 April 2017 / Accepted: 6 May 2017 / Published: 1 June 2017

Abstract

Aim: In the present study, we assessed the diagnostic value of epidermal growth factor (EGF) and cancer antigens 125 (CA125) and 15-3 (CA15-3) in bronchoalveolar lavage fluid (BALF) of lung cancer from 79 enrolled patients with suspected lung cancer. Methods: All patients underwent fibrescopic examination, during which BALF samples were collected. Levels of EGF, CA125, and CA15-3 were determined in BALF using commercially available test kits. Results: The results showed that levels of EGF in BALF were significantly higher in patients with lung cancer than in patients with benign diseases (p < 0.01); no significant differences for CA125 (p = 0.67) or CA15-3 (p = 0.43) in BALF were observed between the lung cancer patients and the non-cancer control subjects. With a cut-off value of 27.22 pg/mL, EGF showed a sensitivity of 63.6% and a specificity of 65.7% in predicting the malignant nature of pulmonary disease. Conclusions: The study findings suggest that levels of EGF are significantly increased in BALF from patients with lung cancer than in BALF from patients with benign disease. Detection of the level of EGF in BALF is proposed as a noninvasive test to identify patients at high risk for lung cancer.
Keywords: lung cancer; bronchoalveolar lavage fluid; epidermal growth factor; cancer antigen 125; cancer antigen 15-3 lung cancer; bronchoalveolar lavage fluid; epidermal growth factor; cancer antigen 125; cancer antigen 15-3

Share and Cite

MDPI and ACS Style

Sun, S.; Chen, Z.; Cao, C.; Wu, B.; Wang, B.; Yu, Y.; Chen, Z.; Hu, Z.; Deng, Z. Diagnostic Value of Epidermal Growth Factor, Cancer Antigen 125, and Cancer Antigen 15-3 in Bronchoalveolar Lavage Fluid of Lung Cancer. Curr. Oncol. 2017, 24, 180-184. https://doi.org/10.3747/co.24.3348

AMA Style

Sun S, Chen Z, Cao C, Wu B, Wang B, Yu Y, Chen Z, Hu Z, Deng Z. Diagnostic Value of Epidermal Growth Factor, Cancer Antigen 125, and Cancer Antigen 15-3 in Bronchoalveolar Lavage Fluid of Lung Cancer. Current Oncology. 2017; 24(3):180-184. https://doi.org/10.3747/co.24.3348

Chicago/Turabian Style

Sun, S., Z. Chen, Chao Cao, B. Wu, B. Wang, Y. Yu, Z. Chen, Z. Hu, and Zaichun Deng. 2017. "Diagnostic Value of Epidermal Growth Factor, Cancer Antigen 125, and Cancer Antigen 15-3 in Bronchoalveolar Lavage Fluid of Lung Cancer" Current Oncology 24, no. 3: 180-184. https://doi.org/10.3747/co.24.3348

APA Style

Sun, S., Chen, Z., Cao, C., Wu, B., Wang, B., Yu, Y., Chen, Z., Hu, Z., & Deng, Z. (2017). Diagnostic Value of Epidermal Growth Factor, Cancer Antigen 125, and Cancer Antigen 15-3 in Bronchoalveolar Lavage Fluid of Lung Cancer. Current Oncology, 24(3), 180-184. https://doi.org/10.3747/co.24.3348

Article Metrics

Back to TopTop