Next Article in Journal
Implementing a Regional Oncology Information System: Approach and Lessons Learned
Previous Article in Journal
Re: Reflections on Screening Mammography and the Early Detection of Breast Cancer
Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
Article

Impact of Screening Mammography on Mortality from Breast Cancer before Age 60 in Women 40 to 49 Years of Age

by 1,2,*, 2, 1, 1 and 1
1
Dalla Lana School of Public Health, University of Toronto, Toronto, ON
2
Women’s College Research Institute, Women’s College Hospital, Toronto, ON
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2014, 21(5), 217-221; https://doi.org/10.3747/co.21.2067
Received: 6 July 2014 / Revised: 11 August 2014 / Accepted: 9 September 2014 / Published: 1 October 2014
Background: Whether screening mammography programs should include women in their 40s is controversial. In Canada, screening of women aged 40–49 years has not been shown to reduce mortality from breast cancer. Given that screening mammography reduces mean tumour size and that tumour size is inversely associated with survival, the lack of benefit seen with screening is puzzling and suggests a possible adverse effect on mortality of mammography or subsequent treatment (or both) that counterbalances the expected benefit derived from downstaging. Methods: We followed 50,436 women 40–49 years of age until age 60 for mortality from breast cancer. Of those women, one half had been randomly assigned to annual mammography and one half to no mammography. The impact of mammography on breast cancer mortality was estimated using a left-censored Cox proportional hazards model. Results: Of 256 deaths from breast cancer recorded in the study cohort, 134 occurred in women allocated to mammography, and 122 occurred in those receiving usual care and not allocated to mammography. The cumulative risk of death from breast cancer to age 60 was 0.53% for women assigned to mammography and 0.48% for women not so assigned. The hazard ratio for breast cancer–specific death associated with 1 or more screening mammograms before age 50 was 1.10 (95% confidence interval: 0.86 to 1.40). Conclusions: Mammography in women 40–49 years of age is associated with a small but nonsignificant increase in the risk of dying of breast cancer before age 60. Caution should be exercised when recommending mammographic screening to women before age 50.
Keywords: breast cancer; screening; mammography; mortality breast cancer; screening; mammography; mortality
MDPI and ACS Style

Narod, S.A.; Sun, P.; Wall, C.; Baines, C.; Miller, A.B. Impact of Screening Mammography on Mortality from Breast Cancer before Age 60 in Women 40 to 49 Years of Age. Curr. Oncol. 2014, 21, 217-221. https://doi.org/10.3747/co.21.2067

AMA Style

Narod SA, Sun P, Wall C, Baines C, Miller AB. Impact of Screening Mammography on Mortality from Breast Cancer before Age 60 in Women 40 to 49 Years of Age. Current Oncology. 2014; 21(5):217-221. https://doi.org/10.3747/co.21.2067

Chicago/Turabian Style

Narod, S.A., P. Sun, C. Wall, C. Baines, and A.B. Miller 2014. "Impact of Screening Mammography on Mortality from Breast Cancer before Age 60 in Women 40 to 49 Years of Age" Current Oncology 21, no. 5: 217-221. https://doi.org/10.3747/co.21.2067

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop