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Current Oncology
Volume 20
Issue 5
10.3747/co.20.1456
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Recurrent Nasopharyngeal Carcinoma: A Clinical Dilemma and Challenge

by
Tao Xu
1,2,
J. Tang
3,
M. Gu
4,*,
L. Liu
5,
W. Wei
1 and
H. Yang
2,*
1
Department of Radiation Oncology, First People’s Hospital of Foshan Affiliated to Sun Yat-Sen University, Foshan, China
2
Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China
3
Department of Otolaryngology, First People’s Hospital of Foshan Affiliated to Sun Yat-Sen University, Foshan, China
4
Department of Radiation Oncology, Cancer Center, Sun Yat-Sen University, Guangzhou, China
5
Department of Radiology, Cancer Center, Sun Yat-Sen University, Guangzhou, China
*
Authors to whom correspondence should be addressed.
Curr. Oncol. 2013, 20(5), 406-419; https://doi.org/10.3747/co.20.1456
Submission received: 10 July 2013 / Revised: 8 August 2013 / Accepted: 11 September 2013 / Published: 1 October 2013

Abstract

Recurrent nasopharyngeal carcinoma, which represents a small proportion of head-and-neck cancers, has a unique set of patho-clinical characteristics. The management of recurrent nasopharyngeal carcinoma remains a challenging clinical problem. Traditional treatments offer limited local control and survival benefits; more seriously, they frequently induce severe late complications. Recently, novel treatment techniques and strategies—including precision radiotherapy, endoscopic surgery or transoral robotic resection, third-generation chemotherapy regimens, and targeted therapies and immunotherapy—have provided new hope for patients with recurrent nasopharyngeal carcinoma. Some of these patients can potentially be cured with modern treatments. However, a lack of adequate evidence makes it difficult for clinicians to apply these powerful techniques and strategies. Individualized management guidelines, full evaluation of quality of life in these patients, and a further understanding of the mechanisms underlying recurrence are future directions for research into recurrent nasopharyngeal carcinoma.
Keywords: nasopharyngeal carcinoma; recurrence; surgery; radiotherapy; chemotherapy; biotherapy nasopharyngeal carcinoma; recurrence; surgery; radiotherapy; chemotherapy; biotherapy

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MDPI and ACS Style

Xu, T.; Tang, J.; Gu, M.; Liu, L.; Wei, W.; Yang, H. Recurrent Nasopharyngeal Carcinoma: A Clinical Dilemma and Challenge. Curr. Oncol. 2013, 20, 406-419. https://doi.org/10.3747/co.20.1456

AMA Style

Xu T, Tang J, Gu M, Liu L, Wei W, Yang H. Recurrent Nasopharyngeal Carcinoma: A Clinical Dilemma and Challenge. Current Oncology. 2013; 20(5):406-419. https://doi.org/10.3747/co.20.1456

Chicago/Turabian Style

Xu, Tao, J. Tang, M. Gu, L. Liu, W. Wei, and H. Yang. 2013. "Recurrent Nasopharyngeal Carcinoma: A Clinical Dilemma and Challenge" Current Oncology 20, no. 5: 406-419. https://doi.org/10.3747/co.20.1456

APA Style

Xu, T., Tang, J., Gu, M., Liu, L., Wei, W., & Yang, H. (2013). Recurrent Nasopharyngeal Carcinoma: A Clinical Dilemma and Challenge. Current Oncology, 20(5), 406-419. https://doi.org/10.3747/co.20.1456

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