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Current Oncology
Volume 20
Issue 3
10.3747/co.20.1230
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Management of Renal Collecting Duct Carcinoma: A Systematic Review and the McMaster Experience

by
S. Dason
1,
C. Allard
1,
A. Sheridan–Jonah
2,
J. Gill
2,
H. Jamshaid
2,
T. Aziz
3,
B. Kajal
3 and
A. Kapoor
1,*
1
Division of Urology, Department of Surgery, McMaster University, Hamilton, ON L8N 4A6, Canada
2
Faculty of Health Sciences, McMaster University, Hamilton, ON L8N 4A6, Canada
3
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8N 4A6, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2013, 20(3), 223-232; https://doi.org/10.3747/co.20.1230
Submission received: 1 March 2013 / Revised: 1 April 2013 / Accepted: 1 May 2013 / Published: 1 June 2013

Abstract

Introduction: Collecting duct carcinoma (CDC) is a rare, aggressive form of renal carcinoma that presents at an advanced stage and has a poor prognosis. Little is known concerning the optimal management of CDC. We present the results of a systematic review addressing the management of CDC and the McMaster University CDC series. Methods: The MEDLINE, Cochrane Library, and EMBASE databases and conference proceedings were searched to identify studies relating to the management of CDC. Included studies reported on a minimum of 10 subjects receiving a single intervention. Series in which an evaluation of therapeutic effectiveness was not possible were excluded. The McMaster University (Hamilton, Ontario) series of 6 cases of CDC were retrospectively reviewed. Results: We identified 3 studies relevant to the management of CDC that included a total of 72 patients. A gemcitabine–cisplatin or –carboplatin regimen resulted in a 26% objective response rate in 23 patients with metastatic CDC. Two additional studies indicated that 49 patients treated with immunotherapy achieved no response. In the McMaster series, cytoreductive nephrectomy was performed in 4 of 6 patients. In 2 patients, MVAC therapy (methotrexate–vinblastine–doxorubicin–cisplatin) achieved no response. No significant therapeutic complications occurred, but survival was poor (median: 11 months; range: 10–33 months). Conclusions: Our review and clinical experience suggest that the current standard of care for metastatic CDC is a gemcitabine–cisplatin regimen.
Keywords: collecting duct carcinoma; Bellini duct carcinoma; renal cell carcinoma; cytoreductive nephrectomy; gemcitabine; cisplatin; MVAC collecting duct carcinoma; Bellini duct carcinoma; renal cell carcinoma; cytoreductive nephrectomy; gemcitabine; cisplatin; MVAC

Share and Cite

MDPI and ACS Style

Dason, S.; Allard, C.; Sheridan–Jonah, A.; Gill, J.; Jamshaid, H.; Aziz, T.; Kajal, B.; Kapoor, A. Management of Renal Collecting Duct Carcinoma: A Systematic Review and the McMaster Experience. Curr. Oncol. 2013, 20, 223-232. https://doi.org/10.3747/co.20.1230

AMA Style

Dason S, Allard C, Sheridan–Jonah A, Gill J, Jamshaid H, Aziz T, Kajal B, Kapoor A. Management of Renal Collecting Duct Carcinoma: A Systematic Review and the McMaster Experience. Current Oncology. 2013; 20(3):223-232. https://doi.org/10.3747/co.20.1230

Chicago/Turabian Style

Dason, S., C. Allard, A. Sheridan–Jonah, J. Gill, H. Jamshaid, T. Aziz, B. Kajal, and A. Kapoor. 2013. "Management of Renal Collecting Duct Carcinoma: A Systematic Review and the McMaster Experience" Current Oncology 20, no. 3: 223-232. https://doi.org/10.3747/co.20.1230

APA Style

Dason, S., Allard, C., Sheridan–Jonah, A., Gill, J., Jamshaid, H., Aziz, T., Kajal, B., & Kapoor, A. (2013). Management of Renal Collecting Duct Carcinoma: A Systematic Review and the McMaster Experience. Current Oncology, 20(3), 223-232. https://doi.org/10.3747/co.20.1230

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