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Current Oncology
Volume 20
Issue 1
10.3747/co.20.1206
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Case Report

When the Tumour Is Not the Culprit: Avascular Necrosis of the Hip in a Patient with Castration-Resistant Prostate Cancer

by
E. Chan
1,2,
G. Chan
2,
L. Ehrlich
3,
P. Hull
4,
H. Kreder
4,
W. Chu
2,
E. Chow
2 and
U. Emmenegger
1,*
1
Division of Medical Oncology, Odette Cancer Centre, Toronto, ON, Canada
2
Department of Radiation Oncology, Odette Cancer Centre, Toronto, ON, Canada
3
Department of Radiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
4
Department of Orthopedic Surgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2013, 20(1), 48-51; https://doi.org/10.3747/co.20.1206
Submission received: 7 January 2013 / Revised: 9 January 2013 / Accepted: 14 January 2013 / Published: 1 February 2013

Abstract

Avascular necrosis (avn) of the hip is a well-documented side effect of corticosteroid therapy, but it has also been described as a complication of radiation and chemotherapy. Many prostate cancer patients undergo treatment with all three of those therapeutic modalities, and yet reported cases of avn of the hip in prostate cancer patients are rare. Symptoms that might potentially alert physicians to this complication are nonspecific and may be attributed to cancer progression, in particular to progressive bone metastasis. Here, we report on a 79-year-old man diagnosed with castration-resistant prostate cancer whose diagnosis of avn of the hip was confounded by his underlying malignancy. We discuss risk factors and diagnostic clues in this differential diagnosis of acute hip pain in patients with castration-resistant prostate cancer. Physicians might maintain a high index of suspicion for avn of the hip in prostate cancer patients presenting with new-onset hip pain. Surgical intervention may help to prevent the appearance of avn-associated pain and the negative impact of advanced avn on overall quality of life.
Keywords: castration-resistant prostate cancer; avascular necrosis; corticosteroid; radiotherapy; chemotherapy; bisphosphonate castration-resistant prostate cancer; avascular necrosis; corticosteroid; radiotherapy; chemotherapy; bisphosphonate

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MDPI and ACS Style

Chan, E.; Chan, G.; Ehrlich, L.; Hull, P.; Kreder, H.; Chu, W.; Chow, E.; Emmenegger, U. When the Tumour Is Not the Culprit: Avascular Necrosis of the Hip in a Patient with Castration-Resistant Prostate Cancer. Curr. Oncol. 2013, 20, 48-51. https://doi.org/10.3747/co.20.1206

AMA Style

Chan E, Chan G, Ehrlich L, Hull P, Kreder H, Chu W, Chow E, Emmenegger U. When the Tumour Is Not the Culprit: Avascular Necrosis of the Hip in a Patient with Castration-Resistant Prostate Cancer. Current Oncology. 2013; 20(1):48-51. https://doi.org/10.3747/co.20.1206

Chicago/Turabian Style

Chan, E., G. Chan, L. Ehrlich, P. Hull, H. Kreder, W. Chu, E. Chow, and U. Emmenegger. 2013. "When the Tumour Is Not the Culprit: Avascular Necrosis of the Hip in a Patient with Castration-Resistant Prostate Cancer" Current Oncology 20, no. 1: 48-51. https://doi.org/10.3747/co.20.1206

APA Style

Chan, E., Chan, G., Ehrlich, L., Hull, P., Kreder, H., Chu, W., Chow, E., & Emmenegger, U. (2013). When the Tumour Is Not the Culprit: Avascular Necrosis of the Hip in a Patient with Castration-Resistant Prostate Cancer. Current Oncology, 20(1), 48-51. https://doi.org/10.3747/co.20.1206

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