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Current Oncology
Volume 17
Issue 5
10.3747/co.v17i5.580
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Review

Low-Grade Spindle-Cell Ameloblastic Carcinoma: Report of an Unusual Case with Immunohistochemical Findings and Review of the Literature

by
C. Jindal
*,
S. Palaskar
,
H. Kaur
and
M. Shankari
Department of Oral and Maxillofacial Pathology, MM College of Dental Sciences and Research, Mullana-133203, Ambala, Haryana, India
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2010, 17(5), 52-57; https://doi.org/10.3747/co.v17i5.580
Submission received: 6 July 2010 / Revised: 8 August 2010 / Accepted: 5 September 2010 / Published: 1 October 2010

Abstract

Spindle-cell differentiation in ameloblastic carcinoma is a rare event. Although reported by many authors, it was first described as a separate entity in 1999 by Slater under the heading “low-grade spindle-cell ameloblastic carcinoma.” Here, we report a case of low-grade spindle-cell ameloblastic carcinoma arising in pre-existing unicystic ameloblastoma. The patient, a 60-year-old Indian woman, had a large irregular swelling in the left mandibular region. Histologically, the lesion was composed of a large cystic cavity with an ameloblastomatous lining and areas showing spindle-cell proliferation. The spindle cells showed hyperchromatism, nuclear pleomorphism, and scattered mitotic figures. To our knowledge, 6 cases of spindle-cell ameloblastic carcinoma have been published to date, and this case appears to be the first reporting malignant transformation with spindle-cell differentiation in unicystic ameloblastoma.
Keywords: spindle cells; ameloblastic carcinoma spindle cells; ameloblastic carcinoma

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MDPI and ACS Style

Jindal, C.; Palaskar, S.; Kaur, H.; Shankari, M. Low-Grade Spindle-Cell Ameloblastic Carcinoma: Report of an Unusual Case with Immunohistochemical Findings and Review of the Literature. Curr. Oncol. 2010, 17, 52-57. https://doi.org/10.3747/co.v17i5.580

AMA Style

Jindal C, Palaskar S, Kaur H, Shankari M. Low-Grade Spindle-Cell Ameloblastic Carcinoma: Report of an Unusual Case with Immunohistochemical Findings and Review of the Literature. Current Oncology. 2010; 17(5):52-57. https://doi.org/10.3747/co.v17i5.580

Chicago/Turabian Style

Jindal, C., S. Palaskar, H. Kaur, and M. Shankari. 2010. "Low-Grade Spindle-Cell Ameloblastic Carcinoma: Report of an Unusual Case with Immunohistochemical Findings and Review of the Literature" Current Oncology 17, no. 5: 52-57. https://doi.org/10.3747/co.v17i5.580

APA Style

Jindal, C., Palaskar, S., Kaur, H., & Shankari, M. (2010). Low-Grade Spindle-Cell Ameloblastic Carcinoma: Report of an Unusual Case with Immunohistochemical Findings and Review of the Literature. Current Oncology, 17(5), 52-57. https://doi.org/10.3747/co.v17i5.580

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