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Case Report

Primary Non-Hodgkin Lymphoma of Liver

1
Cancer Care Center of Frederick, 46B Thomas Johnson Drive, Frederick, MD 21702, USA
2
Deccan College of Medical Sciences, Hyderabad, India
3
Frederick Imaging Center, Frederick, MD, USA
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2009, 16(4), 74-77; https://doi.org/10.3747/co.v16i4.443
Submission received: 9 May 2009 / Revised: 4 June 2009 / Accepted: 7 July 2009 / Published: 1 August 2009

Abstract

Primary non-Hodgkin lymphoma (nhl) of liver is a very rare malignancy. Here, we report the case of a 65-year-old man who presented with constipation and right groin pain of 2 months’ duration. A computed tomography (ct) scan of the abdomen incidentally detected multiple hypodense nodules in both lobes of the liver. Diagnosis of primary nhl of liver was made using ultrasound-guided biopsy. Extensive investigations—which included bone marrow biopsy; fluorescence in situ hybridization; flow cytometry; ct scan of chest, abdomen, and pelvis; and whole-body positron-emission tomography—showed no involvement of bone marrow, lymph nodes, spleen, or any other organ. The patient is currently being treated with a chop-r (cyclophosphamide–doxorubicin–vincristine–prednisolone/rituximab) regimen. The case has many unique features, including normal liver function tests, especially that for lactate dehydrogenase; no type B symptoms; and negative serology for viruses. The case demonstrates that primary hepatic lymphoma should be considered in the differential diagnosis of space-occupying liver lesions in presence of normal levels of alpha-fetoprotein and carcinoembryonic antigen. The literature is extensively reviewed.
Keywords: primary hepatic lymphoma; non-Hodgkin lymphoma; liver; rituximab primary hepatic lymphoma; non-Hodgkin lymphoma; liver; rituximab

Share and Cite

MDPI and ACS Style

Masood, A.; Kairouz, S.; Hudhud, K.H.; Hegazi, A.Z.; Banu, A.; Gupta, N.C. Primary Non-Hodgkin Lymphoma of Liver. Curr. Oncol. 2009, 16, 74-77. https://doi.org/10.3747/co.v16i4.443

AMA Style

Masood A, Kairouz S, Hudhud KH, Hegazi AZ, Banu A, Gupta NC. Primary Non-Hodgkin Lymphoma of Liver. Current Oncology. 2009; 16(4):74-77. https://doi.org/10.3747/co.v16i4.443

Chicago/Turabian Style

Masood, Ashiq, S. Kairouz, K. H. Hudhud, A. Z. Hegazi, A. Banu, and N. C. Gupta. 2009. "Primary Non-Hodgkin Lymphoma of Liver" Current Oncology 16, no. 4: 74-77. https://doi.org/10.3747/co.v16i4.443

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