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Cardiovascular Medicine
Volume 15
Issue 10
10.4414/cvm.2012.00102
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Cardiovascular Medicine is published by MDPI from Volume 28 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Editores Medicorum Helveticorum (EMH).
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Review

Curing by Burning? What to Expect from Renal Denervation in the Treatment of Arterial Hypertension

by
Antoinette Pechère-Bertschia
1,*,
Georg Ehret
2,3,
Marco Roffi
2,
Robert Francis Bonvini
2,
François Mach
2 and
Pierre-Yves Martin
4
1
Hypertension Unit, Division of Endocrinology, Diabetes, Hypertension and Nutrition and of Primary Care Medicine and Emergencies, Geneva University Hospitals, CH-1211 Genève, Switzerland
2
Cardiology Service, Geneva University Hospitals, CH-1211 Genève, Switzerland
3
Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, CH-1010 Lausanne, Switzerland
4
Nephrology Service, Geneva University Hospitals, CH-1211 Genève, Switzerland
*
Author to whom correspondence should be addressed.
Cardiovasc. Med. 2012, 15(10), 271; https://doi.org/10.4414/cvm.2012.00102
Submission received: 24 July 2012 / Revised: 24 August 2012 / Accepted: 24 September 2012 / Published: 24 October 2012
Versions Notes

Abstract

Renal denervation is a new promising intervention for refractory hypertension. It uses ablation of the renal sympathetic nerves with a radio-frequency-emitting catheter inserted percutaneously via the femoral artery into the lumen of both renal arteries. Reducing sympathetic activity with total sympathectomy in order to treat high blood pressure has been utilised in the 1940s but was abandoned for high complication rates. This new, more focalised approach allows for an impressive blood pressure reduction in office blood pressure. New data also show that this method may reduce sleep apnoea syndrome, some parameters of the metabolic syndrome, and heart rate and PR intervals as indicators of reduced sympathetic activity. Altogether, this approach appears to be a safe and effective therapeutic approach to lower blood pressure, but only in highly selected patients with resistant hypertension, and after state-of-the-art optimised treatment in expert centres. A close follow-up of these patients after the procedure is also required. The indications of renal denervation, some technical aspects, perspectives and limitations are developed in this review.
Keywords: renal denervation; sympathetic; resistant hypertension renal denervation; sympathetic; resistant hypertension

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MDPI and ACS Style

Pechère-Bertschia, A.; Ehret, G.; Roffi, M.; Bonvini, R.F.; Mach, F.; Martin, P.-Y. Curing by Burning? What to Expect from Renal Denervation in the Treatment of Arterial Hypertension. Cardiovasc. Med. 2012, 15, 271. https://doi.org/10.4414/cvm.2012.00102

AMA Style

Pechère-Bertschia A, Ehret G, Roffi M, Bonvini RF, Mach F, Martin P-Y. Curing by Burning? What to Expect from Renal Denervation in the Treatment of Arterial Hypertension. Cardiovascular Medicine. 2012; 15(10):271. https://doi.org/10.4414/cvm.2012.00102

Chicago/Turabian Style

Pechère-Bertschia, Antoinette, Georg Ehret, Marco Roffi, Robert Francis Bonvini, François Mach, and Pierre-Yves Martin. 2012. "Curing by Burning? What to Expect from Renal Denervation in the Treatment of Arterial Hypertension" Cardiovascular Medicine 15, no. 10: 271. https://doi.org/10.4414/cvm.2012.00102

APA Style

Pechère-Bertschia, A., Ehret, G., Roffi, M., Bonvini, R. F., Mach, F., & Martin, P.-Y. (2012). Curing by Burning? What to Expect from Renal Denervation in the Treatment of Arterial Hypertension. Cardiovascular Medicine, 15(10), 271. https://doi.org/10.4414/cvm.2012.00102

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