Die Arrhythmogene Rechtsventrikuläre Dysplasie/Kardiomyopathie
Summary
Einleitung
Epidemiologie
Pathologie und Histopathologie
Genetik
Klinik
Diagnostik
Modifizierte 2010-Task-Force-Kriterien (Tab. 2) [25]
- –
- Globale und regionale myokardiale Dysfunktion und strukturelle Veränderungen.
- –
- Histologische Charakterisierung.
- –
- Repolarisationsstörungen im 12-Kanal-Oberflächen-EKG.
- –
- Depolarisationsstörungen im 12-Kanal-Oberflächen-EKG.
- –
- Arrhythmien.
- –
- Positive Familienanamnese.
Klinische Untersuchung
12-Kanal-Oberflächen-EKG und Signal gemitteltes EKG (SAECG)
Echokardiographie, kardiale Magnetresonanz (CMR) und RV-Angiographie
Elektrophysiologische Untersuchung (EPU) und elektroanatomisches Voltage-Mapping
Genetische Testung
Endomyokardiale Biopsie (EMB)
Differentialdiagnosen
Krankheitsverlauf
Es können vier Krankheitsphasen unterschieden werden [1].
- Subklinische Phase, in der bereits diskrete strukturelle Abnormalitäten sichtbar sind, der Patient jedoch vollständig asymptomatisch ist. Dennoch kann es in dieser Phase ohne Prodromi zum SCD als Erstmanifestation kommen. Ein junges Alter per se gilt als Risikofaktor für den SCD [19].
- Auftreten von symptomatischen Arrhythmien aus dem RV (vereinzelte VES bis hin zu anhaltenden KT mit LSB-Morphologie und Kammerflimmern (Abb. 5), die zu Palpitationen, Synkopen und SCD führen können.
- Rechtsherzinsuffizienz mit erhaltener linksventrikulärer Funktion
- Biventrikuläre Herzinsuffizienz in der Spätphase, die einer ausgeprägten dilatativen Kardiomyopathie ähnelt und bis zu einem Herzersatzverfahren führen kann. In dieser Phase werden auch endokardiale Thromben beobachtet, die zu pulmonalen und systemischen Embolien führen können [40].
Behandlung
Appendix
Etablierung eines universitären Programms mit Schwerpunkt ARVD/C
- spezialsprechstunde für arvD/c-Patienten
- 2.
- arvD/c-register
- 3.
- wissenschaftliche und klinische forschungsprojekte
- 4.
- arvD/c wissenschaftliche veranstaltungen
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Saguner, A.M.; Brunckhorst, C.; Duru, F. Die Arrhythmogene Rechtsventrikuläre Dysplasie/Kardiomyopathie. Cardiovasc. Med. 2011, 14, 303. https://doi.org/10.4414/cvm.2011.01623
Saguner AM, Brunckhorst C, Duru F. Die Arrhythmogene Rechtsventrikuläre Dysplasie/Kardiomyopathie. Cardiovascular Medicine. 2011; 14(11):303. https://doi.org/10.4414/cvm.2011.01623
Chicago/Turabian StyleSaguner, Ardan M., Corinna Brunckhorst, and Firat Duru. 2011. "Die Arrhythmogene Rechtsventrikuläre Dysplasie/Kardiomyopathie" Cardiovascular Medicine 14, no. 11: 303. https://doi.org/10.4414/cvm.2011.01623
APA StyleSaguner, A. M., Brunckhorst, C., & Duru, F. (2011). Die Arrhythmogene Rechtsventrikuläre Dysplasie/Kardiomyopathie. Cardiovascular Medicine, 14(11), 303. https://doi.org/10.4414/cvm.2011.01623