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Biomarkers of Immunotoxicity for Environmental and Public Health Research

Genentech, Inc., 1 DNA Way MS #59, South San Francisco, CA 94080, USA
School of Public Health, University of California, Berkeley, 733 University Hall, Berkeley, CA 94720-7360, USA
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2011, 8(5), 1388-1401;
Received: 18 February 2011 / Revised: 26 March 2011 / Accepted: 25 April 2011 / Published: 6 May 2011
(This article belongs to the Special Issue Biomarkers: Environmental Research and Public Health)
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The immune response plays an important role in the pathophysiology of numerous diseases including asthma, autoimmunity and cancer. Application of biomarkers of immunotoxicity in epidemiology studies and human clinical trials can improve our understanding of the mechanisms that underlie the associations between environmental exposures and development of these immune-mediated diseases. Immunological biomarkers currently used in environmental health studies include detection of key components of innate and adaptive immunity (e.g., complement, immunoglobulin and cell subsets) as well as functional responses and activation of key immune cells. The use of high-throughput assays, including flow cytometry, Luminex, and Multi-spot cytokine detection methods can further provide quantitative analysis of immune effects. Due to the complexity and redundancy of the immune response, an integrated assessment of several components of the immune responses is needed. The rapidly expanding field of immunoinformatics will also aid in the synthesis of the vast amount of data being generated. This review discusses and provides examples of how the identification and development of immunological biomarkers for use in studies of environmental exposures and immune-mediated disorders can be achieved. View Full-Text
Keywords: asthma; COPD; biomarker validation; immunoinformatics; Luminex; immunome; immunotoxicity asthma; COPD; biomarker validation; immunoinformatics; Luminex; immunome; immunotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Duramad, P.; Holland, N.T. Biomarkers of Immunotoxicity for Environmental and Public Health Research. Int. J. Environ. Res. Public Health 2011, 8, 1388-1401.

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