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Volume 7
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Review

Maternal Diet, Behaviour and Offspring Skeletal Health

by
Laura R. Goodfellow
,
Susannah Earl
,
Cyrus Cooper
and
Nicholas C. Harvey
*
Medical Research Council Epidemiology Resource Centre, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2010, 7(4), 1760-1772; https://doi.org/10.3390/ijerph7041760
Submission received: 24 December 2009 / Revised: 10 March 2010 / Accepted: 15 April 2010 / Published: 16 April 2010
(This article belongs to the Special Issue Health Behaviors and Public Health)
Versions Notes

Abstract

Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass. Recent work has suggested epigenetic mechanisms as key to these observations. This review will explore the role of the early environment in determining later osteoporotic fracture risk.
Keywords: osteoporosis; epigenetic; early life origins; fracture; bone mass; vitamin D; neonate; fetus osteoporosis; epigenetic; early life origins; fracture; bone mass; vitamin D; neonate; fetus

Share and Cite

MDPI and ACS Style

Goodfellow, L.R.; Earl, S.; Cooper, C.; Harvey, N.C. Maternal Diet, Behaviour and Offspring Skeletal Health. Int. J. Environ. Res. Public Health 2010, 7, 1760-1772. https://doi.org/10.3390/ijerph7041760

AMA Style

Goodfellow LR, Earl S, Cooper C, Harvey NC. Maternal Diet, Behaviour and Offspring Skeletal Health. International Journal of Environmental Research and Public Health. 2010; 7(4):1760-1772. https://doi.org/10.3390/ijerph7041760

Chicago/Turabian Style

Goodfellow, Laura R., Susannah Earl, Cyrus Cooper, and Nicholas C. Harvey. 2010. "Maternal Diet, Behaviour and Offspring Skeletal Health" International Journal of Environmental Research and Public Health 7, no. 4: 1760-1772. https://doi.org/10.3390/ijerph7041760

APA Style

Goodfellow, L. R., Earl, S., Cooper, C., & Harvey, N. C. (2010). Maternal Diet, Behaviour and Offspring Skeletal Health. International Journal of Environmental Research and Public Health, 7(4), 1760-1772. https://doi.org/10.3390/ijerph7041760

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