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Association of Dietary Patterns with MRI Markers of Hepatic Inflammation and Fibrosis in the MAST4HEALTH Study

Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 17671 Athens, Greece
Center for Diagnostic Imaging, Oncology Institute of Vojvodine, 21204 Sremska Kamenica, Serbia
Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia
Department of Biology, Faculty of Technology Zvornik, University of East Sarajevo, 75400 Zvornik, Bosnia and Herzegovina
Perspectum Ltd., Oxford OX4 2LL, UK
Chios Mastic Gum Growers Association, 82100 Chios, Greece
Clinical Studies Group, Randox Laboratories Ltd., Crumlin BT29 4RN, UK
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 60596 Frankfurt, Germany
Area de Genòmica i Salut, Fundació per al Foment de la Investigació Sanitá ria I Biomèdica de la Comunitat Valenciana (FISABIO-Salut Pú blica), 46020 Valencia, Spain
CIBER en Epidemiología y Salud Pú blica, 28029 Madrid, Spain
INSERM UMR U1122, IGE-PCV, Faculté de Pharmacie, Université de Lorraine, 30 Rue Lionnois, 54000 Nancy, France
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
Centre for Genomic Health, Life Sciences, Queen Mary University of London, London E1 2AD, UK
Biotechvana, Parc Científic, Universitat de València, Paterna, 46010 Valencia, Spain
Intervideo Web Service, 88100 Catanzaro, Italy
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Vojvodina, 21000 Novi Sad, Serbia
Institute of Clinical Physiology National Research Council, 56124 Pisa, Italy
ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy
Authors to whom correspondence should be addressed.
Academic Editors: Aristea Gioxari, Stefano Ballestri and Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2022, 19(2), 971;
Received: 27 November 2021 / Revised: 7 January 2022 / Accepted: 13 January 2022 / Published: 16 January 2022
(This article belongs to the Special Issue New Advances in Nutrition and Health)
Whereas the etiology of non-alcoholic fatty liver disease (NAFLD) is complex, the role of nutrition as a causing and preventive factor is not fully explored. The aim of this study is to associate dietary patterns with magnetic resonance imaging (MRI) parameters in a European population (Greece, Italy, and Serbia) affected by NAFLD. For the first time, iron-corrected T1 (cT1), proton density fat fraction (PDFF), and the liver inflammation fibrosis score (LIF) were examined in relation to diet. A total of 97 obese patients with NAFLD from the MAST4HEALTH study were included in the analysis. A validated semi-quantitative food frequency questionnaire (FFQ) was used to assess the quality of diet and food combinations. Other variables investigated include anthropometric measurements, total type 2 diabetes risk, physical activity level (PAL), and smoking status. Principal component analysis (PCA) was performed to identify dietary patterns. Six dietary patterns were identified, namely “High-Sugar”, “Prudent”, “Western”, “High-Fat and Salt”, “Plant-Based”, and “Low-Fat Dairy and Poultry”. The “Western” pattern was positively associated with cT1 in the unadjusted model (beta: 0.020, p-value: 0.025) and even after adjusting for age, sex, body mass index (BMI), PAL, smoking, the center of the study, and the other five dietary patterns (beta: 0.024, p-value: 0.020). On the contrary, compared with low-intake patients, those with medium intake of the “Low-Fat Dairy and Poultry” pattern were associated with lower values of cT1, PDFF, and LIF. However, patients with a “Low-Fat Dairy and Poultry” dietary pattern were negatively associated with MRI parameters (cT1: beta: −0.052, p-value: 0.046, PDFF: beta: −0.448, p-value: 0.030, LIF: beta: −0.408, p-value: 0.025). Our findings indicate several associations between MRI parameters and dietary patterns in NAFLD patients, highlighting the importance of diet in NAFLD. View Full-Text
Keywords: NAFLD; NASH; MRI; dietary patterns; MAST4HEALTH NAFLD; NASH; MRI; dietary patterns; MAST4HEALTH
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MDPI and ACS Style

Amanatidou, A.I.; Kaliora, A.C.; Amerikanou, C.; Stojanoski, S.; Milosevic, N.; Vezou, C.; Beribaka, M.; Banerjee, R.; Kalafati, I.-P.; Smyrnioudis, I.; Kurth, M.J.; Kannt, A.; Francino, M.P.; Visvikis-Siest, S.; Deloukas, P.; Llorens, C.; Marascio, F.; Milic, N.; Medic-Stojanoska, M.; Gastaldelli, A.; Trivella, M.G.; Dedoussis, G.V. Association of Dietary Patterns with MRI Markers of Hepatic Inflammation and Fibrosis in the MAST4HEALTH Study. Int. J. Environ. Res. Public Health 2022, 19, 971.

AMA Style

Amanatidou AI, Kaliora AC, Amerikanou C, Stojanoski S, Milosevic N, Vezou C, Beribaka M, Banerjee R, Kalafati I-P, Smyrnioudis I, Kurth MJ, Kannt A, Francino MP, Visvikis-Siest S, Deloukas P, Llorens C, Marascio F, Milic N, Medic-Stojanoska M, Gastaldelli A, Trivella MG, Dedoussis GV. Association of Dietary Patterns with MRI Markers of Hepatic Inflammation and Fibrosis in the MAST4HEALTH Study. International Journal of Environmental Research and Public Health. 2022; 19(2):971.

Chicago/Turabian Style

Amanatidou, Athina I., Andriana C. Kaliora, Charalampia Amerikanou, Stefan Stojanoski, Natasa Milosevic, Chara Vezou, Mirjana Beribaka, Rajarshi Banerjee, Ioanna-Panagiota Kalafati, Ilias Smyrnioudis, Mary J. Kurth, Aimo Kannt, M. P. Francino, Sophie Visvikis-Siest, Panos Deloukas, Carlos Llorens, Fernando Marascio, Natasa Milic, Milica Medic-Stojanoska, Amalia Gastaldelli, Maria G. Trivella, and George V. Dedoussis. 2022. "Association of Dietary Patterns with MRI Markers of Hepatic Inflammation and Fibrosis in the MAST4HEALTH Study" International Journal of Environmental Research and Public Health 19, no. 2: 971.

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