Comparison of Concordance of Peptic Ulcer Disease, Non-Adenomatous Intestinal Polyp, and Gallstone Disease in Korean Monozygotic and Dizygotic Twins: A Cross-Sectional Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population and Data Collection
2.2. Participants Selection
2.3. Survey
2.4. Exposure
2.5. Outcome
2.6. Statistical Analyses
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristics | Total Participants | |||
---|---|---|---|---|
Monozygotic Twin | Dizygotic Twin | p-Value | ||
Age (years old, n, %) | 0.004 * | |||
20–24 | 6 (0.6) | 0 (0) | ||
25–29 | 68 (6.5) | 4 (1.6) | ||
30–34 | 362 (34.5) | 87 (35.7) | ||
35–39 | 244 (23.2) | 65 (26.6) | ||
40–44 | 139 (13.2) | 36 (14.8) | ||
45–49 | 129 (12.3) | 20 (8.2) | ||
50–54 | 82 (7.8) | 22 (9) | ||
55–59 | 14 (1.3) | 10 (4.1) | ||
60–64 | 4 (0.4) | 0 (0) | ||
65+ | 2 (0.2) | 0 (0) | ||
Sex (n, %) | 0.016 * | |||
Males | 384 (36.6) | 134 (54.9) | ||
Females | 666 (63.4) | 244 (100) | ||
Income (n, %) | 0.978 | |||
<2 million (KRW) | 349 (33.2) | 81 (33.2) | ||
2 to <3 million (KRW) | 282 (26.9) | 68 (27.9) | ||
3 to <4 million (KRW) | 214 (20.4) | 50 (20.5) | ||
≥4 million (KRW) | 205 (19.5) | 45 (18.4) | ||
Education (n, %) | 0.743 | |||
Under high school | 122 (11.6) | 25 (10.2) | ||
Graduated from high school | 371 (35.3) | 92 (37.7) | ||
Commercial college/dropped out of college | 123 (11.7) | 32 (13.1) | ||
Graduated from high school | 434 (41.3) | 95 (38.9) | ||
Marriage (n, %) | 0.302 | |||
Unmarried | 240 (23.1) | 50 (20.5) | ||
Married | 733 (70.5) | 173 (70.9) | ||
Divorced or others | 67 (6.4) | 21 (8.6) | ||
Physical Activity | ||||
Hard (hour/week, mean, SD) | 3.1 (6.8) | 4.7 (9.7) | 0.013 * | |
Moderate (hour/week, mean, SD) | 5.8 (10.5) | 6.2 (10.2) | 0.612 | |
Walk (hour/week, mean, SD) | 6.1 (9.6) | 6.8 (10.9) | 0.291 | |
Sit (hour/week, mean, SD) | 40.1 (22) | 37.9 (20.7) | 0.155 | |
Obesity (n, %) | 0.203 | |||
Underweight (BMI < 18.5) | 27 (2.6) | 5 (2) | ||
Normal (BMI ≥ 18.5 to < 23) | 510 (48.6) | 113 (46.3) | ||
Overweight (BMI 23 to < 25) | 220 (21) | 68 (27.9) | ||
Obese I (BMI ≥ 25 to < 30) | 261 (24.9) | 52 (21.3) | ||
Obese II (BMI ≥ 30) | 32 (3) | 6 (2.5) | ||
Smoking status (n, %) | 0.138 | |||
Nonsmoker | 691 (65.8) | 145 (59.4) | ||
Past smoker | 108 (10.3) | 33 (13.5) | ||
Current smoker | 251 (23.9) | 66 (27) | ||
Frequency of drinking alcohol (n, %) | 0.314 | |||
Nondrinker | 304 (29) | 64 (26.2) | ||
≤1 time per month | 238 (22.7) | 46 (18.9) | ||
2–4 times per month | 300 (28.6) | 80 (32.8) | ||
≥2 times per week | 208 (19.8) | 54 (22.1) | ||
Sleeping hours (n, %) | 0.370 | |||
≤5 h | 53 (5) | 16 (6.6) | ||
6–7 h | 619 (59) | 146 (59.8) | ||
8–9 h | 350 (33.3) | 72 (29.5) | ||
≥10 h | 28 (2.7) | 10 (4.1) | ||
Gastrointestinal diseases (categorical) | ||||
Gastric/duodenal ulcer (n, %) | 111 (10.6) | 32 (13.1) | 0.254 | |
Intestinal polyp (n, %) | 23 (2.2) | 3 (1.2) | 0.451 | |
Cholelithiasis/cholangitis (n, %) | 35 (3.3) | 5 (2) | 0.319 |
Concordance of Diseases | Monozygotic Twin | Dizygotic Twin | Odds Ratios (95% Confidence Interval) | |||||
---|---|---|---|---|---|---|---|---|
n (%) | n (%) | Crude | p | Model 1 † | p | Model 2 ‡ | p | |
Gastric/duodenal ulcer | ||||||||
concordant | 878/1050 (83.6) | 190/244 (77.9) | 1.45 (1.03–2.05) | 0.034 * | 1.28 (0.89–1.86) | 0.187 | 1.30 (0.90–1.88) | 0.169 |
discordant | 172/1050 (16.4) | 54/244 (22.1) | 1 | 1 | 1 | |||
Intestinal polyp | ||||||||
concordant | 1008/1050 (96.0) | 238/244 (97.5) | 0.61 (0.25–1.44) | 0.256 | 0.32 (0.11–0.88) | 0.028 * | 0.32 (0.11–0.89) | 0.028 * |
discordant | 42/1050 (4.0) | 6/244 (2.5) | 1 | 1 | 1 | |||
Cholelithiasis/cholangitis | ||||||||
concordant | 990/1050 (94.3) | 234/244 (95.9) | 0.71 (0.36–1.44) | 0.317 | 0.62 (0.30–1.29) | 0.204 | 0.61 (0.30–1.27) | 0.190 |
discordant | 60/1050 (5.7) | 10/244 (4.1) | 1 | 1 | 1 |
Concordance of Diseases | Monozygotic Twin | Dizygotic Twin | Odds Ratios (95% CI) | |||||
---|---|---|---|---|---|---|---|---|
n (%) | n (%) | Crude | p | Model 1 * | p | Model 2 † | p | |
Gastric/duodenal ulcer | ||||||||
Positive-positive | 24/1050 (2.3) | 6/244 (2.5) | 0.86 (0.35–2.14) | 0.748 | 1.01 (0.39–2.63) | 0.990 | 1.00 (0.38–2.61) | 0.994 |
Positive-negative | 172/1050 (16.4) | 54/244 (22.1) | 0.69 (0.49–0.97) | 0.032 * | 0.73 (0.51–1.05) | 0.088 | 0.72 (0.51–1.04) | 0.077 |
Negative-negative | 854/1050 (81.3) | 184/244 (75.4) | 1 | 1 | 1 | |||
Intestinal polyp | ||||||||
Positive-positive | 2/1050 (0.2) | 0/244 (0.0) | N/A | N/A | N/A | N/A | N/A | N/A |
Positive-negative | 42/1050 (4.0) | 6/244 (2.5) | 1.66 (0.70–3.94) | 0.254 | 2.04 (0.82–5.07) | 0.125 | 2.05 (0.82–5.11) | 0.124 |
Negative-negative | 1006/1050 (95.8) | 238/244 (97.5) | 1 | 1 | 1 | |||
Cholelithiasis/cholangitis | ||||||||
Positive-positive | 6/1050 (0.6) | 0/244 (0.0) | N/A | N/A | N/A | N/A | N/A | N/A |
Positive-negative | 60/1050 (5.7) | 10/244 (4.1) | 1.43 (0.72–2.83) | 0.309 | 1.57 (0.78–3.16) | 0.209 | 1.58 (0.78–3.19) | 0.201 |
Negative-negative | 984/1050 (93.7) | 234/244 (95.9) | 1 | 1 | 1 |
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Choi, H.G.; Kim, S.Y.; Lim, H.; Kim, J.-H.; Kim, J.H.; Cho, S.-J.; Nam, E.S.; Min, K.-W.; Park, H.Y.; Kim, N.Y.; et al. Comparison of Concordance of Peptic Ulcer Disease, Non-Adenomatous Intestinal Polyp, and Gallstone Disease in Korean Monozygotic and Dizygotic Twins: A Cross-Sectional Study. Int. J. Environ. Res. Public Health 2022, 19, 12708. https://doi.org/10.3390/ijerph191912708
Choi HG, Kim SY, Lim H, Kim J-H, Kim JH, Cho S-J, Nam ES, Min K-W, Park HY, Kim NY, et al. Comparison of Concordance of Peptic Ulcer Disease, Non-Adenomatous Intestinal Polyp, and Gallstone Disease in Korean Monozygotic and Dizygotic Twins: A Cross-Sectional Study. International Journal of Environmental Research and Public Health. 2022; 19(19):12708. https://doi.org/10.3390/ijerph191912708
Chicago/Turabian StyleChoi, Hyo Geun, So Young Kim, Hyun Lim, Joo-Hee Kim, Ji Hee Kim, Seong-Jin Cho, Eun Sook Nam, Kyueng-Whan Min, Ha Young Park, Nan Young Kim, and et al. 2022. "Comparison of Concordance of Peptic Ulcer Disease, Non-Adenomatous Intestinal Polyp, and Gallstone Disease in Korean Monozygotic and Dizygotic Twins: A Cross-Sectional Study" International Journal of Environmental Research and Public Health 19, no. 19: 12708. https://doi.org/10.3390/ijerph191912708