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Volume 19
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10.3390/ijerph19116485
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Article

Effects of Commercial Probiotics on Colonic Sensitivity after Acute Mucosal Irritation

by
Laura López-Gómez
1,2,
Jaime Antón
1,
Yolanda López-Tofiño
1,2,
Bianca Pomana
1,
José A. Uranga
1,2,* and
Raquel Abalo
1,2,3,4,*
1
Department of Basic Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain
2
High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut-URJC), University Rey Juan Carlos, 28922 Alcorcón, Spain
3
Associated I+D+i Unit to the Institute of Medicinal Chemistry (IQM), Scientific Research Superior Council (CSIC), 28006 Madrid, Spain
4
Working Group of Basic Sciences in Pain and Analgesia of the Spanish Society of Pain, 28046 Madrid, Spain
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2022, 19(11), 6485; https://doi.org/10.3390/ijerph19116485
Submission received: 15 March 2022 / Revised: 23 May 2022 / Accepted: 24 May 2022 / Published: 26 May 2022
(This article belongs to the Special Issue 2nd Edition of New Perspectives in Health: Gut Microbiota)
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Abstract

Gastrointestinal pathologies associated with abdominal pain, such as irritable bowel syndrome or inflammatory bowel disease, lack sufficiently effective treatments. In our study we have used a rat model of visceral pain (72 animals; n = 8–13 per experimental group) to analyze the consequences of intracolonic administration of the irritant acetic acid on visceral sensitivity, histology of the colonic wall, and inflammatory response. Moreover, we have studied the possible beneficial effects of a pretreatment with a commercial probiotic (Actimel®). Contrary to expectations, acetic acid application (7 cm proximal to the anus) decreased the nociceptive response to intracolonic mechanical stimulation, with a slight increase in the histological damage of colonic mucosa. The intensity of these changes depended on the concentration (4% or 0.6%) and the time of application (30 or 60 min). Pretreatment with probiotics (by daily gavage, for 1 week) normalized the values obtained in the visceral sensitivity test but revealed an increase in the number of macrophages. These results suggest a possible activation of inhibitory mechanisms early after colonic irritation, not previously described (which need further experimental confirmation), and the ability of probiotics to normalize the effects of acetic acid. In addition, pretreatment with probiotics has a direct effect on immune functions, stimulating macrophagic activity.
Keywords: animal model; inflammatory bowel disease; irritable bowel syndrome; probiotics; visceral pain animal model; inflammatory bowel disease; irritable bowel syndrome; probiotics; visceral pain
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MDPI and ACS Style

López-Gómez, L.; Antón, J.; López-Tofiño, Y.; Pomana, B.; Uranga, J.A.; Abalo, R. Effects of Commercial Probiotics on Colonic Sensitivity after Acute Mucosal Irritation. Int. J. Environ. Res. Public Health 2022, 19, 6485. https://doi.org/10.3390/ijerph19116485

AMA Style

López-Gómez L, Antón J, López-Tofiño Y, Pomana B, Uranga JA, Abalo R. Effects of Commercial Probiotics on Colonic Sensitivity after Acute Mucosal Irritation. International Journal of Environmental Research and Public Health. 2022; 19(11):6485. https://doi.org/10.3390/ijerph19116485

Chicago/Turabian Style

López-Gómez, Laura, Jaime Antón, Yolanda López-Tofiño, Bianca Pomana, José A. Uranga, and Raquel Abalo. 2022. "Effects of Commercial Probiotics on Colonic Sensitivity after Acute Mucosal Irritation" International Journal of Environmental Research and Public Health 19, no. 11: 6485. https://doi.org/10.3390/ijerph19116485

APA Style

López-Gómez, L., Antón, J., López-Tofiño, Y., Pomana, B., Uranga, J. A., & Abalo, R. (2022). Effects of Commercial Probiotics on Colonic Sensitivity after Acute Mucosal Irritation. International Journal of Environmental Research and Public Health, 19(11), 6485. https://doi.org/10.3390/ijerph19116485

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