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Volume 18
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Article

Significantly Reduced Alanine Aminotransferase Level Increases All-Cause Mortality Rate in the Elderly after Ischemic Stroke

by
Sang Joon An
1,†,
Yun-Jung Yang
2,†,
Na-mo Jeon
3,
Yeon-Pyo Hong
4,
Yeong In Kim
1 and
Doo-Young Kim
3,*
1
Department of Neurology, Catholic Kwandong University International St Mary’s Hospital, Incheon 22711, Korea
2
Institute of Biomedical Science, Catholic Kwandong University International St. Mary’s Hospital, Incheon 22711, Korea
3
Department of Rehabilitation Medicine, Catholic Kwandong University International St Mary’s Hospital, Incheon 22711, Korea
4
Department of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul 06974, Korea
*
Author to whom correspondence should be addressed.
†
Sang Joon An and Yun-Jung Yang contributed equally to this work.
Int. J. Environ. Res. Public Health 2021, 18(9), 4915; https://doi.org/10.3390/ijerph18094915
Submission received: 17 March 2021 / Revised: 2 May 2021 / Accepted: 2 May 2021 / Published: 5 May 2021
(This article belongs to the Special Issue Real-World Evidence in Clinical Epidemiology and Public Health)
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Abstract

(1) Background: A significantly reduced alanine aminotransferase (ALT) level is being recognized as a risk factor of increasing mortality in the elderly in relation to frailty. In the elderly, both frailty and ischemic stroke are not only common, but are also associated with mortality. The aim of this research was to investigate whether a significantly reduced ALT level increases the all-cause mortality rate in the elderly with ischemic stroke. (2) Methods: Between February 2014 and April 2019, a retrospective study of 901 patients with ischemic stroke admitted to a university-affiliated hospital was conducted. Cox proportional hazard regression was used to determine whether a significantly reduced ALT level is an independent risk factor for mortality in elderly patients after an ischemic stroke. (3) Results: This study enrolled 323 older adults (age ≥ 65 years) who were first diagnosed with ischemic stroke. The mean age of the participants was 76.5 ± 6.6 years, the mean survival time was 37.1 ± 20.4 months, and the number of deaths was 96 (29.7%). Our results showed that reduced ALT level (less than 10 U/L) increased the risk of all-cause mortality in the elderly after ischemic stroke (adjusted HR: 3.24, 95% CI: 1.95–5.41; p < 0.001). (4) Conclusions: A significantly reduced ALT level at the time of diagnosis (less than 10 U/L) is an independent risk factor that increases the mortality rate in the elderly after ischemic stroke.
Keywords: aged; alanine transaminase; brain infarction; frailty; mortality aged; alanine transaminase; brain infarction; frailty; mortality

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MDPI and ACS Style

An, S.J.; Yang, Y.-J.; Jeon, N.-m.; Hong, Y.-P.; Kim, Y.I.; Kim, D.-Y. Significantly Reduced Alanine Aminotransferase Level Increases All-Cause Mortality Rate in the Elderly after Ischemic Stroke. Int. J. Environ. Res. Public Health 2021, 18, 4915. https://doi.org/10.3390/ijerph18094915

AMA Style

An SJ, Yang Y-J, Jeon N-m, Hong Y-P, Kim YI, Kim D-Y. Significantly Reduced Alanine Aminotransferase Level Increases All-Cause Mortality Rate in the Elderly after Ischemic Stroke. International Journal of Environmental Research and Public Health. 2021; 18(9):4915. https://doi.org/10.3390/ijerph18094915

Chicago/Turabian Style

An, Sang Joon, Yun-Jung Yang, Na-mo Jeon, Yeon-Pyo Hong, Yeong In Kim, and Doo-Young Kim. 2021. "Significantly Reduced Alanine Aminotransferase Level Increases All-Cause Mortality Rate in the Elderly after Ischemic Stroke" International Journal of Environmental Research and Public Health 18, no. 9: 4915. https://doi.org/10.3390/ijerph18094915

APA Style

An, S. J., Yang, Y.-J., Jeon, N.-m., Hong, Y.-P., Kim, Y. I., & Kim, D.-Y. (2021). Significantly Reduced Alanine Aminotransferase Level Increases All-Cause Mortality Rate in the Elderly after Ischemic Stroke. International Journal of Environmental Research and Public Health, 18(9), 4915. https://doi.org/10.3390/ijerph18094915

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