Co-Circulation of Bovine Leukemia Virus Haplotypes among Humans, Animals, and Food Products: New Insights of Its Zoonotic Potential

Corredor-Figueroa, Adriana P.; Olaya-Galán, Nury N.; Velandia-Álvarez, Sebastian; Muñoz, Marina; Salas-Cárdenas, Sandra P.; Ibáñez-Pinilla, Milcíades; Patarroyo, Manuel A.; Gutiérrez, Maria F.

doi:10.3390/ijerph18094883

Open AccessArticle

Co-Circulation of Bovine Leukemia Virus Haplotypes among Humans, Animals, and Food Products: New Insights of Its Zoonotic Potential

by

Adriana P. Corredor-Figueroa

^1,2,†

,

Nury N. Olaya-Galán

^1,3,*,†

,

Sebastian Velandia-Álvarez

¹

,

Marina Muñoz

⁴

,

Sandra P. Salas-Cárdenas

¹,

Milcíades Ibáñez-Pinilla

⁵

,

Manuel A. Patarroyo

^6,7,8

and

Maria F. Gutiérrez

¹

Grupo de Enfermedades Infecciosas, Laboratorio de Virología, Departamento de Microbiología, Pontificia Universidad Javeriana, Bogota 110231, Colombia

²

Vicerrectoría de Investigación, Universidad ECCI, Bogota 111311, Colombia

³

PhD Program in Biomedical and Biological Sciences, Universidad del Rosario, Bogota 111221, Colombia

⁴

Centro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogota 111221, Colombia

⁵

Research Department, Hospital Universitario Mayor Méderi—Universidad del Rosario, Bogota 111411, Colombia

⁶

Molecular Biology and Immunology Department, Fundación Instituto de Inmunología de Colombia (FIDIC), Bogota 111321, Colombia

⁷

Microbiology Department, Faculty of Medicine, Universidad Nacional de Colombia, Bogota 111321, Colombia

⁸

Health Sciences Division, Main Campus, Universidad Santo Tomás, Bogota 110231, Colombia

^*

Author to whom correspondence should be addressed.

^†

These two authors contributed equally as first authors.

Int. J. Environ. Res. Public Health 2021, 18(9), 4883; https://doi.org/10.3390/ijerph18094883

Submission received: 26 February 2021 / Revised: 21 March 2021 / Accepted: 22 March 2021 / Published: 4 May 2021

(This article belongs to the Special Issue Animals as Environmental Sentinels of Humans Infections)

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Abstract

Bovine leukemia virus (BLV) is the causative agent of leukemia/lymphoma in cattle. It has been found in humans and cattle-derived food products. In humans, it is described as a potential risk factor for breast cancer development. However, the transmission path remains unclear. Here, a molecular epidemiology analysis was performed to identify signatures of genetic flux of BLV among humans, animals, and food products. Sequences obtained from these sources in Colombia were used (n = 183) and compared with reference sequences available in GenBank. Phylogenetic reconstruction was performed in IQ-TREE software with the maximum likelihood algorithm. Haplotype (hap) distribution among the population was carried out with a median-joining model in Network5.0. Recombination events were inferred using SplitsTree4 software. In the phylogenetic analysis, no specific branches were identified for the Colombian sequences or for the different sources. A total of 31 haps were found, with Hap 1, 4, 5 and 7 being shared among the three sources of the study. Reticulation events among the different sources were also detected during the recombination analysis. These results show new insights about the zoonotic potential of BLV, showing evidence of genetic flux between cattle and humans. Prevention and control strategies should be considered to avoid viral dissemination as part of the One Health program policies.

Keywords: molecular epidemiology; bovine leukemia virus; haplotypes; zoonoses; recombination analysis

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MDPI and ACS Style

Corredor-Figueroa, A.P.; Olaya-Galán, N.N.; Velandia-Álvarez, S.; Muñoz, M.; Salas-Cárdenas, S.P.; Ibáñez-Pinilla, M.; Patarroyo, M.A.; Gutiérrez, M.F. Co-Circulation of Bovine Leukemia Virus Haplotypes among Humans, Animals, and Food Products: New Insights of Its Zoonotic Potential. Int. J. Environ. Res. Public Health 2021, 18, 4883. https://doi.org/10.3390/ijerph18094883

AMA Style

Corredor-Figueroa AP, Olaya-Galán NN, Velandia-Álvarez S, Muñoz M, Salas-Cárdenas SP, Ibáñez-Pinilla M, Patarroyo MA, Gutiérrez MF. Co-Circulation of Bovine Leukemia Virus Haplotypes among Humans, Animals, and Food Products: New Insights of Its Zoonotic Potential. International Journal of Environmental Research and Public Health. 2021; 18(9):4883. https://doi.org/10.3390/ijerph18094883

Chicago/Turabian Style

Corredor-Figueroa, Adriana P., Nury N. Olaya-Galán, Sebastian Velandia-Álvarez, Marina Muñoz, Sandra P. Salas-Cárdenas, Milcíades Ibáñez-Pinilla, Manuel A. Patarroyo, and Maria F. Gutiérrez. 2021. "Co-Circulation of Bovine Leukemia Virus Haplotypes among Humans, Animals, and Food Products: New Insights of Its Zoonotic Potential" International Journal of Environmental Research and Public Health 18, no. 9: 4883. https://doi.org/10.3390/ijerph18094883

APA Style

Corredor-Figueroa, A. P., Olaya-Galán, N. N., Velandia-Álvarez, S., Muñoz, M., Salas-Cárdenas, S. P., Ibáñez-Pinilla, M., Patarroyo, M. A., & Gutiérrez, M. F. (2021). Co-Circulation of Bovine Leukemia Virus Haplotypes among Humans, Animals, and Food Products: New Insights of Its Zoonotic Potential. International Journal of Environmental Research and Public Health, 18(9), 4883. https://doi.org/10.3390/ijerph18094883

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Co-Circulation of Bovine Leukemia Virus Haplotypes among Humans, Animals, and Food Products: New Insights of Its Zoonotic Potential

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