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Article

Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data

1
Drug Utilization Work Group, Spanish Society of Family and Community Medicine (semFYC), ES-08009 Barcelona, Spain
2
Dirección del Servicio Canario de la Salud, Plan de Salud de Canarias, ES-38004 Santa Cruz de Tenerife, Spain
3
Centro de Salud de Paterna, Conselleria de Sanitat Universal i Salut Pública, Generalitat Valenciana, ES-46980 Valencia, Spain
4
Centro de Salud Son Serra-La Vileta, Servicio de Salud de las Islas Baleares Ib-salut, ES-07013 Palma, Spain
5
Institut d’Investigació Sanitaria Illes Balears (IDISBA), Servicio de Salud de las Islas Baleares Ib-salut, ES-07120 Palma de Mallorca, Spain
6
Centro de Salud Delicias Sur, Servicio Aragonés de Salud, ES-50009 Zaragoza, Spain
7
EpiChron Research Group on Chronic Diseases, Aragon Health Research Institute (IIS Aragón), ES-50009 Zaragoza, Spain
8
Ministerio de Sanidad, Consumo y Bienestar Social, ES-28014 Madrid, Spain
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Hospital de Denia. Marina Salud, Conselleria de Sanitat Universal i Salut Pública, Generalitat Valenciana, ES-03700 Alicante, Spain
10
Centro de Salud de Sillería, Servicio de Salud de Castilla-La Mancha, ES-45001 Toledo, Spain
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Centro de Salud de Sádaba, Servicio Aragonés de Salud, ES-50670 Zaragoza, Spain
12
Centro de Salud de Sueca, Conselleria de Sanitat Universal i Salut Pública, Generalitat Valenciana, ES-46410 Valencia, Spain
13
Centro de Salud de Huarte, Servicio Navarro de Salud, ES-31620 Pamplona, Spain
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Centro de Salud de Canalejas, Servicio Canario de la Salud, ES-35004 Las Palmas de Gran Canaria, Spain
15
Departamento de Farmacología y Pediatría, Facultad de Medicina, Universidad de Málaga, ES-29010 Málaga, Spain
16
Vaksinasjonssenter BSN, Bydel Søndre Nordstrand, Oslo kommune, NO-1252 Oslo, Norway
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2021, 18(9), 4754; https://doi.org/10.3390/ijerph18094754
Received: 22 March 2021 / Revised: 22 April 2021 / Accepted: 26 April 2021 / Published: 29 April 2021
We aimed to identify and compare medication profiles in populations with polypharmacy between 2005 and 2015. We conducted a cross-sectional study using information from the Computerized Database for Pharmacoepidemiologic Studies in Primary Care (BIFAP, Spain). We estimated the prevalence of therapeutic subgroups in all individuals 15 years of age and older with polypharmacy (≥5 drugs during ≥6 months) using the Anatomical Therapeutic Chemical classification system level 4, by sex and age group, for both calendar years. The most prescribed drugs were proton-pump inhibitors (PPIs), statins, antiplatelet agents, benzodiazepine derivatives, and angiotensin-converting enzyme inhibitors. The greatest increases between 2005 and 2015 were observed in PPIs, statins, other antidepressants, and β-blockers, while the prevalence of antiepileptics was almost tripled. We observed increases in psychotropic drugs in women and cardiovascular medications in men. By patient´s age groups, there were notable increases in antipsychotics, antidepressants, and antiepileptics (15–44 years); antidepressants, PPIs, and selective β-blockers (45–64 years); selective β-blockers, biguanides, PPIs, and statins (65–79 years); and in statins, selective β-blockers, and PPIs (80 years and older). Our results revealed important increases in the use of specific therapeutic subgroups, like PPIs, statins, and psychotropic drugs, highlighting opportunities to design and implement strategies to analyze such prescriptions’ appropriateness. View Full-Text
Keywords: computerized medical records systems; drug utilization; electronic prescribing; pharmacoepidemiology; polypharmacy; real-world data; Spain computerized medical records systems; drug utilization; electronic prescribing; pharmacoepidemiology; polypharmacy; real-world data; Spain
MDPI and ACS Style

Hernández-Rodríguez, M.Á.; Sempere-Verdú, E.; Vicens-Caldentey, C.; González-Rubio, F.; Miguel-García, F.; Palop-Larrea, V.; Orueta-Sánchez, R.; Esteban-Jiménez, Ó.; Sempere-Manuel, M.; Arroyo-Aniés, M.P.; Fernández-San José, B.; de Juan-Roldán, J.I.; Ioakeim-Skoufa, I. Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data. Int. J. Environ. Res. Public Health 2021, 18, 4754. https://doi.org/10.3390/ijerph18094754

AMA Style

Hernández-Rodríguez MÁ, Sempere-Verdú E, Vicens-Caldentey C, González-Rubio F, Miguel-García F, Palop-Larrea V, Orueta-Sánchez R, Esteban-Jiménez Ó, Sempere-Manuel M, Arroyo-Aniés MP, Fernández-San José B, de Juan-Roldán JI, Ioakeim-Skoufa I. Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data. International Journal of Environmental Research and Public Health. 2021; 18(9):4754. https://doi.org/10.3390/ijerph18094754

Chicago/Turabian Style

Hernández-Rodríguez, Miguel Á., Ermengol Sempere-Verdú, Caterina Vicens-Caldentey, Francisca González-Rubio, Félix Miguel-García, Vicente Palop-Larrea, Ramón Orueta-Sánchez, Óscar Esteban-Jiménez, Mara Sempere-Manuel, María P. Arroyo-Aniés, Buenaventura Fernández-San José, José I. de Juan-Roldán, and Ignatios Ioakeim-Skoufa. 2021. "Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data" International Journal of Environmental Research and Public Health 18, no. 9: 4754. https://doi.org/10.3390/ijerph18094754

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