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Open AccessArticle

Histomorphometric Comparison between Two Types of Acellular Dermal Matrix Grafts: A Mini Pig Animal Model Study

1
Department of Medicine and Medical Specialties, Faculty of Health Sciences, University of Alcalá, 28871 Alcalá de Henares, Spain
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Department of Preclinical Dentistry, School of Biomedical Sciences, Universidad Europea de Madrid, 28670 Villaviciosa de Odón, Spain
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Department of Dentistry, Federico Henriquez y Carvajal University, 11005 Santo Domingo, Dominican Republic
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Faculty of Dentistry, Universidad Alfonso X El Sabio, 28961 Villanueva de la Cañada, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Adriano Piattelli and Margherita Tumedei
Int. J. Environ. Res. Public Health 2021, 18(8), 3881; https://doi.org/10.3390/ijerph18083881
Received: 11 March 2021 / Revised: 31 March 2021 / Accepted: 6 April 2021 / Published: 7 April 2021
Acellular dermal matrix grafts (ADMG) have been used as soft tissue graft substitutes for autografts in periodontal plastic surgical procedures. They have benefits like avoiding a second surgical site and patient morbidity that have been associated with autografts, but there is limited evidence available on their tissue response and wound healing process. This histomorphometric animal model study was carried out in mini pigs and it aimed to compare the two types of ADMG materials of human and porcine derivative with a control group through observation of parameters like epithelial and Keratinized layer thickness, angiogenesis, cellularity, matrix resorption, and inflammatory infiltrate. The surgical technique involved punctures on the edentulous areas stripping the epithelial tissue and exposing the underlying connective tissue, placement of the ADMGs in the appropriate control and test sites. Following this, gingival biopsies were procured at three different time intervals of 15, 45, and 90 days. There were significant differences in epithelial and Keratinized layer thickness among the three groups. This study concluded that there was no clear consensus on which graft material was superior but it gave an insight into the tissue response and wound healing process associated with the graft materials. View Full-Text
Keywords: animal model; acellular dermal matrix graft; angiogenesis; keratin; wound healing animal model; acellular dermal matrix graft; angiogenesis; keratin; wound healing
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MDPI and ACS Style

Aragoneses, J.; Suárez, A.; Rodríguez, C.; Aragoneses, J.M. Histomorphometric Comparison between Two Types of Acellular Dermal Matrix Grafts: A Mini Pig Animal Model Study. Int. J. Environ. Res. Public Health 2021, 18, 3881. https://doi.org/10.3390/ijerph18083881

AMA Style

Aragoneses J, Suárez A, Rodríguez C, Aragoneses JM. Histomorphometric Comparison between Two Types of Acellular Dermal Matrix Grafts: A Mini Pig Animal Model Study. International Journal of Environmental Research and Public Health. 2021; 18(8):3881. https://doi.org/10.3390/ijerph18083881

Chicago/Turabian Style

Aragoneses, Javier; Suárez, Ana; Rodríguez, Cinthia; Aragoneses, Juan M. 2021. "Histomorphometric Comparison between Two Types of Acellular Dermal Matrix Grafts: A Mini Pig Animal Model Study" Int. J. Environ. Res. Public Health 18, no. 8: 3881. https://doi.org/10.3390/ijerph18083881

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