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The Effects of Childhood Maltreatment on Non-Suicidal Self-Injury in Male Adolescents: The Moderating Roles of the Monoamine Oxidase A (MAOA) Gene and the Catechol-O-Methyltransferase (COMT) Gene

Institute of Developmental Psychology, Beijing Normal University, Beijing 100875, China
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Author to whom correspondence should be addressed.
Academic Editor: Antonella Agodi
Int. J. Environ. Res. Public Health 2021, 18(5), 2598; https://doi.org/10.3390/ijerph18052598
Received: 22 January 2021 / Revised: 22 February 2021 / Accepted: 2 March 2021 / Published: 5 March 2021
(1) Background: Numerous studies suggest strong associations between childhood maltreatment and nonsuicidal self-injury (NSSI); this is also true for the roles of dopaminergic genes in the etiology of some psychopathologies related to NSSI. Investigating the interactions of environments and genes is important in order to better understand the etiology of NSSI. (2) Methods: Within a sample of 269 Chinese male adolescents (Mage = 14.72, SD = 0.92), childhood maltreatment and NSSI were evaluated, and saliva samples were collected for MAOA T941G and COMT Val158Met polymorphism analyses. (3) Results: The results revealed no primary effects attributable to MAOA T941G and COMT Val158Met polymorphism on NSSI. However, there was a significant three-way interaction between MAOA, COMT, and child abuse (β = −0.34, p < 0.01) in adolescent NSSI. Except for carriers of the T allele of MAOA and the Met allele of COMT, all studied male adolescents displayed higher NSSI scores when exposed to a higher level of child abuse. A similar three-way interaction was not observed in the case of child neglect. (4) Conclusions: The results indicate that the MAOA gene and COMT gene play moderating roles in the association between child abuse and NSSI of male adolescents and suggest the polygenic underpinnings of NSSI. View Full-Text
Keywords: childhood maltreatment; MAOA gene; COMT gene; adolescent NSSI; gene–gene–environment interaction childhood maltreatment; MAOA gene; COMT gene; adolescent NSSI; gene–gene–environment interaction
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MDPI and ACS Style

Gao, Y.; Xiong, Y.; Liu, X.; Wang, H. The Effects of Childhood Maltreatment on Non-Suicidal Self-Injury in Male Adolescents: The Moderating Roles of the Monoamine Oxidase A (MAOA) Gene and the Catechol-O-Methyltransferase (COMT) Gene. Int. J. Environ. Res. Public Health 2021, 18, 2598. https://doi.org/10.3390/ijerph18052598

AMA Style

Gao Y, Xiong Y, Liu X, Wang H. The Effects of Childhood Maltreatment on Non-Suicidal Self-Injury in Male Adolescents: The Moderating Roles of the Monoamine Oxidase A (MAOA) Gene and the Catechol-O-Methyltransferase (COMT) Gene. International Journal of Environmental Research and Public Health. 2021; 18(5):2598. https://doi.org/10.3390/ijerph18052598

Chicago/Turabian Style

Gao, Yemiao, Yuke Xiong, Xia Liu, and Hui Wang. 2021. "The Effects of Childhood Maltreatment on Non-Suicidal Self-Injury in Male Adolescents: The Moderating Roles of the Monoamine Oxidase A (MAOA) Gene and the Catechol-O-Methyltransferase (COMT) Gene" International Journal of Environmental Research and Public Health 18, no. 5: 2598. https://doi.org/10.3390/ijerph18052598

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