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Article

Impact of Fibromyalgia in the Hippocampal Subfields Volumes of Women—An MRI Study

1
Physical Activity and Quality of Life Research Group (AFYCAV), Faculty of Sport Sciences, University of Extremadura, Av. De Universidad s/n, 10003 Caceres, Spain
2
International Institute for Innovation in Aging, University of Extremadura, 10003 Caceres, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(4), 1549; https://doi.org/10.3390/ijerph18041549
Received: 12 January 2021 / Revised: 1 February 2021 / Accepted: 2 February 2021 / Published: 6 February 2021
(This article belongs to the Section Health Behavior, Chronic Disease and Health Promotion)
Patients with fibromyalgia (FM) show widespread pain associated with other symptoms such as cognitive problems, depression, and anxiety among others associated with alterations in the central nervous system. The hippocampal subfields had differences in function, histology, and connectivity with other brain regions, and are altered in different diseases. This study evaluates the volumetric differences between patients with FM compared with a healthy control group. A total of 49 women with, and 43 healthy women completed this study. T1-weighted MRI was used to assess brain volume, and FreeSurfer software was used to segment the hippocampal subfields. Women with FM had a significant reduction in most of the hippocampal subfields. The regression equation models were obtained to predict the volume of specific subfields of the right and left hippocampus. These findings provide that women with FM have lower hippocampal subfields volumes compared with healthy women. Besides, regression models show that different covariates, such as age, cognitive impairment, or depression, are related to specific subfields. View Full-Text
Keywords: chronic pain; hippocampus; brain; cognitive impairment chronic pain; hippocampus; brain; cognitive impairment
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MDPI and ACS Style

Leon-Llamas, J.L.; Villafaina, S.; Murillo-Garcia, A.; Gusi, N. Impact of Fibromyalgia in the Hippocampal Subfields Volumes of Women—An MRI Study. Int. J. Environ. Res. Public Health 2021, 18, 1549. https://doi.org/10.3390/ijerph18041549

AMA Style

Leon-Llamas JL, Villafaina S, Murillo-Garcia A, Gusi N. Impact of Fibromyalgia in the Hippocampal Subfields Volumes of Women—An MRI Study. International Journal of Environmental Research and Public Health. 2021; 18(4):1549. https://doi.org/10.3390/ijerph18041549

Chicago/Turabian Style

Leon-Llamas, Juan L., Santos Villafaina, Alvaro Murillo-Garcia, and Narcis Gusi. 2021. "Impact of Fibromyalgia in the Hippocampal Subfields Volumes of Women—An MRI Study" International Journal of Environmental Research and Public Health 18, no. 4: 1549. https://doi.org/10.3390/ijerph18041549

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