Influence of Catechol-O-Methyltransferase Gene Polymorphism on the Correlation between Alexithymia and Hypervigilance to Pain
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. PVAQ
2.3. TAS-20
2.4. DNA Amplification and Genotyping of COMT Polymorphism
2.5. Statistical Analysis
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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PVAQ-AP | PVAQ-ACP | TAS-20-DIF | TAS-20-DDF | TAS-20-EOT | |
---|---|---|---|---|---|
Val/Val group | 23.3 ± 7.1 | 16.4 ± 4.2 | 17.7 ± 6.6 | 15.9 ± 3.9 | 20.4 ± 3.4 |
Met-carrier group | 24.7 ± 8.1 | 17.1 ± 6.06 | 13.7 ± 4.7 | 14.6 ± 3.4 | 21.2 ± 3.6 |
p value | p = 0.612 | p = 0.666 | p = 0.059 | p = 0.299 | p = 0.492 |
TAS-20-DIF | TAS-20-DDF | TAS-20-EOT | ||
---|---|---|---|---|
PVAQ-AP | All subjects | r = 0.255 p = 0.134 | r = 0.145 p = 0.40 | r = 0.091 p = 0.599 |
Val/Val group | r = 0.143 p = 0.573 | r = 0.206 p = 0.413 | r = 0.278 p = 0.264 | |
Met-carrier group | r = 0.426 p = 0.078 | r = 0.124 p = 0.623 | r = −0.080 p = 0.753 | |
PVAQ-ACP | All subjects | r = 0.474 p = 0.004 * | r = 0.156 p = 0.363 | r = −0.146 p = 0.395 |
Val/Val group | r = 0.244 p = 0.329 | r = 0.158 p = 0.530 | r = 0.088 p = 0.729 | |
Met-carrier group | r = 0.73 p = 0.001 * | r = 0.194 p = 0.440 | r = −0.316 p = 0.201 |
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Ikarashi, H.; Otsuru, N.; Yokota, H.; Nagasaka, K.; Igarashi, K.; Miyaguchi, S.; Onishi, H. Influence of Catechol-O-Methyltransferase Gene Polymorphism on the Correlation between Alexithymia and Hypervigilance to Pain. Int. J. Environ. Res. Public Health 2021, 18, 13265. https://doi.org/10.3390/ijerph182413265
Ikarashi H, Otsuru N, Yokota H, Nagasaka K, Igarashi K, Miyaguchi S, Onishi H. Influence of Catechol-O-Methyltransferase Gene Polymorphism on the Correlation between Alexithymia and Hypervigilance to Pain. International Journal of Environmental Research and Public Health. 2021; 18(24):13265. https://doi.org/10.3390/ijerph182413265
Chicago/Turabian StyleIkarashi, Hitomi, Naofumi Otsuru, Hirotake Yokota, Kazuaki Nagasaka, Kazuki Igarashi, Shota Miyaguchi, and Hideaki Onishi. 2021. "Influence of Catechol-O-Methyltransferase Gene Polymorphism on the Correlation between Alexithymia and Hypervigilance to Pain" International Journal of Environmental Research and Public Health 18, no. 24: 13265. https://doi.org/10.3390/ijerph182413265
APA StyleIkarashi, H., Otsuru, N., Yokota, H., Nagasaka, K., Igarashi, K., Miyaguchi, S., & Onishi, H. (2021). Influence of Catechol-O-Methyltransferase Gene Polymorphism on the Correlation between Alexithymia and Hypervigilance to Pain. International Journal of Environmental Research and Public Health, 18(24), 13265. https://doi.org/10.3390/ijerph182413265