Current Thoughts of Notch’s Role in Myoblast Regulation and Muscle-Associated Disease
Abstract
1. Introduction
2. The Public Health Concern of Skeletal Muscle Diseases
3. Notch during Embryogenesis
4. Notch and the Adult Skeletal Muscle Tissue
5. Notch Promotes Myoblast Proliferation and Inhibits Differentiation
5.1. Notch’s Effect on Proliferation and Differentiation Using Cell Culture Models
5.2. Notch’s Effect on Proliferation and Differentiation in Rodent Models
5.3. Manipulating O-fucosylation Activity to Study Notch’s Effect on Proliferation and Differentiation
5.4. Manipulating Sialylation Activity to Study Notch’s Effect on Proliferation and Differentiation: Cell Culture and Rodent Models
6. Mechanisms of Notch’s Action on Proliferation and Differentiation
6.1. Notch’s Effects on Proliferation/Differentiation through Pax7
6.2. Notch’s Effects on Proliferation/Differentiation through Hes/Hey
6.3. Notch’s Effects on Proliferation/Differentiation through Myoblast Transmembranes
6.4. Notch’s Effects on Proliferation/Differentiation through NUMB
6.5. Notch’s Effects on Proliferation/Differentiation through Signaling Pathways
7. Conflicting Thoughts on Notch’s Role in Proliferation and Differentiation in Skeletal Muscle
8. Dysfunctional Notch Signaling
9. Aging and Vitamin D deficiency
9.1. Vitamin D Deficiency in Mice and Rats
9.2. Vitamin D Deficiency in Humans
10. Age-Related Notch Signaling Deficiencies
10.1. Notch Signaling and FGF-2
10.2. Notch and TGF-B
11. Anabolic Hormone Decrements
12. Cachexia
13. Muscular Dystrophy
14. Diabetes
14.1. Type 1 Diabetes
14.2. Type II Diabetes
15. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Model | Observation of Myoblasts | References (Cell Culture or Rodent Models) |
---|---|---|
Force activation of Notch in satellite cells | ↑ proliferation ↓ differentiation | Qin (2013) [22] (cell culture), Vasyutina E (2007) [23] (cell culture) Noguchi (2019) [24] (rodent) |
NICD (overexpressed Notch) to inhibit Pax7 in Pax7-expressing cells | ↓ differentiation | Wen et al. [36] (rodent) |
Silenced Pax7 w/siRNA in RH30 PAX7+ cells | ↓ proliferation ↑ differentiation | Skrzypek et al. [39] (cell culture) |
Overexpressing YAP in atrophied chick embryos | ↓ differentiation | Esteves de Lima et al. [40] (rodent) |
Hes1 mutation plasmid in primary muscle stem cells | ↓ differentiation | Lahmann et al. [41] (cell culture) |
MEGF-10 knockout in primary myoblasts | ↓ proliferation | Saha et al. [42] (rodent) |
Smo inhibitor on Shh in C2C12 cells | ↓ proliferation | Ma et al. [29] (cell culture) |
Stra13 knockout in mice Active Stra13 inhibits Notch in mice | ↑ proliferation ↓ proliferation ↑ differentiation | Sun et al. [43] (rodent) |
Gamma secretase inhibitor (DAPT) inhibits PGE2/EP2 | ↑ differentiation | Sakai-Takemura et al. [28] (cell culture) |
Inhibiting sialylation Active sialylation | ↓ proliferation ↑ proliferation | Vergé (2020) [32] (cell culture) |
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Gerrard, J.C.; Hay, J.P.; Adams, R.N.; Williams, J.C., III; Huot, J.R.; Weathers, K.M.; Marino, J.S.; Arthur, S.T. Current Thoughts of Notch’s Role in Myoblast Regulation and Muscle-Associated Disease. Int. J. Environ. Res. Public Health 2021, 18, 12558. https://doi.org/10.3390/ijerph182312558
Gerrard JC, Hay JP, Adams RN, Williams JC III, Huot JR, Weathers KM, Marino JS, Arthur ST. Current Thoughts of Notch’s Role in Myoblast Regulation and Muscle-Associated Disease. International Journal of Environmental Research and Public Health. 2021; 18(23):12558. https://doi.org/10.3390/ijerph182312558
Chicago/Turabian StyleGerrard, Jeffrey C., Jamison P. Hay, Ryan N. Adams, James C. Williams, III, Joshua R. Huot, Kaitlin M. Weathers, Joseph S. Marino, and Susan T. Arthur. 2021. "Current Thoughts of Notch’s Role in Myoblast Regulation and Muscle-Associated Disease" International Journal of Environmental Research and Public Health 18, no. 23: 12558. https://doi.org/10.3390/ijerph182312558
APA StyleGerrard, J. C., Hay, J. P., Adams, R. N., Williams, J. C., III, Huot, J. R., Weathers, K. M., Marino, J. S., & Arthur, S. T. (2021). Current Thoughts of Notch’s Role in Myoblast Regulation and Muscle-Associated Disease. International Journal of Environmental Research and Public Health, 18(23), 12558. https://doi.org/10.3390/ijerph182312558