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Article

Deep Venous Thrombosis and Risk of Consequent Sepsis Event: A Retrospective Nationwide Population-Based Cohort Study

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Graduate School of Dentistry, School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan
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Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
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Department of Anesthesiology, Changhua Christian Hospital, Changhua 50006, Taiwan
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Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
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Department of Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan
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Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
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School of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan
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Chang Gung Memorial Hospital, Linkou, Taoyuan City 33302, Taiwan
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Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
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Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
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Department of Family Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan
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Department of Surgery, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to the work.
Academic Editor: Beatriz Garcia-Fontana
Int. J. Environ. Res. Public Health 2021, 18(15), 7879; https://doi.org/10.3390/ijerph18157879
Received: 4 June 2021 / Revised: 21 July 2021 / Accepted: 23 July 2021 / Published: 25 July 2021
(This article belongs to the Special Issue Cardiovascular Diseases and Healthy Aging)
Deep vein thrombosis causes several acute and chronic vessel complications and puts patients at risk of subsequent sepsis development. This unique study aimed to estimate the risk of sepsis development in DVT patients compared with non-DVT patients. This population-based cohort study used records of a longitudinal health insurance database containing two million patients defined in Taiwan’s National Health Insurance Research Database (NHIRD). Our study included patients aged over 20 years with a new diagnosis of DVT with at least two outpatient department visits or an admission between 2001 and 2014. Patients with a diagnosis of sepsis before the index date were excluded. Propensity score matching (PSM) was used to homogenize the baseline characteristics between the two groups. To define the independent risk of the DVT group, a multivariate Cox proportional hazard model was used to estimate the hazard ratios. After PSM, the DVT group (n = 5753) exhibited a higher risk of sepsis (adjusted hazard ratio, aHR, 1.74; 95% CI, 1.59–1.90) compared with non-DVT group (n = 5753). Patients with an increased risk of sepsis were associated with being elderly aged, male, having diabetes, chronic kidney disease, chronic obstructive pulmonary disease, stroke, malignancy, and use of antibiotics. In conclusion, this population-based cohort study demonstrated an increased risk of sepsis in DVT patients compared with non-DVT patients. Thus, early prevention and adequate treatment of DVT is necessary in clinical practice. View Full-Text
Keywords: sepsis; deep vein thrombosis; cohort study sepsis; deep vein thrombosis; cohort study
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MDPI and ACS Style

Yeh, Y.-T.; Tsai, S.-E.; Chen, Y.-C.; Yang, S.-F.; Yeh, H.-W.; Wang, B.-Y.; Yeh, L.-T.; Shih, N.-C.; Wang, Y.-H.; Chen, Y.-Y.; Yeh, C.-B. Deep Venous Thrombosis and Risk of Consequent Sepsis Event: A Retrospective Nationwide Population-Based Cohort Study. Int. J. Environ. Res. Public Health 2021, 18, 7879. https://doi.org/10.3390/ijerph18157879

AMA Style

Yeh Y-T, Tsai S-E, Chen Y-C, Yang S-F, Yeh H-W, Wang B-Y, Yeh L-T, Shih N-C, Wang Y-H, Chen Y-Y, Yeh C-B. Deep Venous Thrombosis and Risk of Consequent Sepsis Event: A Retrospective Nationwide Population-Based Cohort Study. International Journal of Environmental Research and Public Health. 2021; 18(15):7879. https://doi.org/10.3390/ijerph18157879

Chicago/Turabian Style

Yeh, Ying-Tung, Sheng-En Tsai, Ying-Cheng Chen, Shun-Fa Yang, Han-Wei Yeh, Bo-Yuan Wang, Liang-Tsai Yeh, Nai-Chen Shih, Yu-Hsun Wang, Yin-Yang Chen, and Chao-Bin Yeh. 2021. "Deep Venous Thrombosis and Risk of Consequent Sepsis Event: A Retrospective Nationwide Population-Based Cohort Study" International Journal of Environmental Research and Public Health 18, no. 15: 7879. https://doi.org/10.3390/ijerph18157879

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