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Article

Diagnostic Accuracy of a New Antigen Test for SARS-CoV-2 Detection

1
Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
2
Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
3
Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
4
Department of Health of the Region of Sicily, CRQ (Regional Laboratory Quality Control Centre), 90145 Palermo, Italy
5
Anesthesia and Reanimation Service “Santa Maria della Pietà” Hospital, 80026 Casoria, Italy
6
Laboratory and Clinical Analysis Service “Santa Maria della Pietà” Hospital, 80026 Casoria, Italy
7
Italian Ministry of Health, USMAF SASN, 80133 Naples, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Danila de Vito, Davide Farronato, Marco Tatullo and Joan Puig-Barberà
Int. J. Environ. Res. Public Health 2021, 18(12), 6310; https://doi.org/10.3390/ijerph18126310
Received: 10 May 2021 / Revised: 8 June 2021 / Accepted: 8 June 2021 / Published: 10 June 2021
(This article belongs to the Special Issue Basics of Hygiene in Public Health and Health Promotion)
Background and aims: Quick and reliable diagnostic tools play an important role in controlling the spread of the SARS-Cov-2 pandemic. The aim of this study was to evaluate the diagnostic accuracy of a new cyto-salivary antigen test aimed at detecting the presence of antigens for SARS-CoV-2, as compared by the gold standard RT-PCR and a lateral flow test. Methods: A total of 433 healthy volunteers were enrolled in the study and the sensitivity and specificity of the new cyto-salivary antigen test were calculated, as compared to the RT-PCR nasopharyngeal swab and to the lateral flow test. Results: A total of 433 samples were collected and tested at the Mediterranean Fair in Palermo from February 2021 until April 2021. The new cyto-salivary antigen had a sensitivity of 100% and a specificity of 94.2%. The sensitivity and the specificity of the lateral flow test were 55% and 100%, respectively. Conclusions: The new cyto-salivary antigen test detected more positive cases than the RT-PCR in a sample of asymptomatic subjects, demonstrating to be a promising tool for a more sensitive diagnosis of COVID-19. Further studies are warranted to better characterize its diagnostic accuracy. View Full-Text
Keywords: respiratory disease COVID-19; SARS-CoV-2; ELISA; cyto-salivary test; RT-PCR; lateral flow test respiratory disease COVID-19; SARS-CoV-2; ELISA; cyto-salivary test; RT-PCR; lateral flow test
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MDPI and ACS Style

Di Domenico, M.; De Rosa, A.; Di Gaudio, F.; Internicola, P.; Bettini, C.; Salzano, N.; Castrianni, D.; Marotta, A.; Boccellino, M. Diagnostic Accuracy of a New Antigen Test for SARS-CoV-2 Detection. Int. J. Environ. Res. Public Health 2021, 18, 6310. https://doi.org/10.3390/ijerph18126310

AMA Style

Di Domenico M, De Rosa A, Di Gaudio F, Internicola P, Bettini C, Salzano N, Castrianni D, Marotta A, Boccellino M. Diagnostic Accuracy of a New Antigen Test for SARS-CoV-2 Detection. International Journal of Environmental Research and Public Health. 2021; 18(12):6310. https://doi.org/10.3390/ijerph18126310

Chicago/Turabian Style

Di Domenico, Marina; De Rosa, Alfredo; Di Gaudio, Francesca; Internicola, Pietro; Bettini, Cinzia; Salzano, Nicola; Castrianni, Davide; Marotta, Andrea; Boccellino, Mariarosaria. 2021. "Diagnostic Accuracy of a New Antigen Test for SARS-CoV-2 Detection" Int. J. Environ. Res. Public Health 18, no. 12: 6310. https://doi.org/10.3390/ijerph18126310

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