Next Article in Journal
The Effect of The Daily Mile on Primary School Children’s Aerobic Fitness Levels After 12 Weeks: A Controlled Trial
Next Article in Special Issue
Illness, Self-Rated Health and Access to Medical Care among Waste Pickers in Landfill Sites in Johannesburg, South Africa
Previous Article in Journal
The Effect of Nordic Walking Training with Poles with an Integrated Resistance Shock Absorber on the Functional Fitness of Women over the Age of 60
Previous Article in Special Issue
Determination of Propane-1,3-sultone in Workplace Air for Occupational Exposure Assessment
Open AccessArticle

Environmental Monitoring of PAHs Exposure, Biomarkers and Vital Status in Coke Oven Workers

1
Interdisciplinary Department of Medicine, Occupational Medicine “B. Ramazzini”, University of Bari Medical School, 11 G. Cesare Square, 70124 Bari, Italy
2
Strategic Regional Health and Social Agency of Puglia (AReS Puglia), 52 G. Gentile Street, 70126 Bari, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(7), 2199; https://doi.org/10.3390/ijerph17072199 (registering DOI)
Received: 28 January 2020 / Revised: 11 March 2020 / Accepted: 20 March 2020 / Published: 25 March 2020
(This article belongs to the Special Issue Air Pollution: Occupational Exposure and Public Health)
A follow-up study of a cohort of workers from a coke plant compared with a control group from the same industrial area was conducted in 2019. The recruitment and environmental and biomarker measurements were performed during 1993/1994. The environmental concentrations of polycyclic aromatic hydrocarbons (PAH), B(a)P, pyrene and nitro-PAH were measured. Personal data were collected via an individual semi-structured questionnaire by a trained physician. All biomarkers were measured after a specific blood drawing for every test. Significant risks (ORs) were observed for nitro-PAH (0.12 µg/m3) [OR = 7.96 (1.01–62.82)], urinary 1-hydroxypyrene (1-OHpy) (≥0.99 µmoles/moles of creatinine) [OR = 11.71 (1.47–92.90)], PAH DNA adducts (P32) (≥2.69 adducts/108 nucleotides) [OR = 5.46 (1.17–25.58)], total nitro-PAH hemoglobin adducts (≥161.68 fg/µg of Hb) [OR = 5.92 (1.26–27.86)], sister chromatid exchange (SCE) with TCR (≥377.84 SCE/cell chromosomes) [OR = 13.06 (3.95–93.10)], sister chromatid exchange with T (≥394.72 total SCE) [OR = 13.06 (3.95–93.10)], and sister chromatid exchange with X (≥8.19 mean SCE) [OR = 13.06 (3.95–93.10)]. Significant risk of death for all causes and chromosomal aberrations (48 h) (OR = 7.19 [1.19–43.44]) or micronuclei in culture at 48 h (OR = 3.86 [1.04–14.38]) were also found. View Full-Text
Keywords: cohort; coke plant; biomarkers; vital status; occupational exposure; sister chromatid exchange; urinary 1-hydroxypyrene (1-OHpy), PAH DNA adducts; total nitro-PAH hemoglobin adducts cohort; coke plant; biomarkers; vital status; occupational exposure; sister chromatid exchange; urinary 1-hydroxypyrene (1-OHpy), PAH DNA adducts; total nitro-PAH hemoglobin adducts
Show Figures

Figure 1

MDPI and ACS Style

Vimercati, L.; Bisceglia, L.; Cavone, D.; Caputi, A.; De Maria, L.; Delfino, M.C.; Corrado, V.; Ferri, G.M. Environmental Monitoring of PAHs Exposure, Biomarkers and Vital Status in Coke Oven Workers. Int. J. Environ. Res. Public Health 2020, 17, 2199.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop