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Open AccessArticle

Acute Kidney Injury Biomarker Responses to Short-Term Heat Acclimation

Center for Research and Education in Special Environments, Department of Exercise and Nutrition Sciences, University at Buffalo, SUNY, Buffalo, NY 14214, USA
Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR 72701, USA
Korey Stringer Institute, Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA
Department of Kinesiology, School of Public Health—Bloomington, Indiana University, Bloomington, IN 47405, USA
Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(4), 1325;
Received: 6 January 2020 / Revised: 15 February 2020 / Accepted: 17 February 2020 / Published: 19 February 2020
(This article belongs to the Special Issue Exercise and Human Temperature Regulation)
The combination of hyperthermia, dehydration, and strenuous exercise can result in severe reductions in kidney function, potentially leading to acute kidney injury (AKI). We sought to determine whether six days of heat acclimation (HA) mitigates the rise in clinical biomarkers of AKI during strenuous exercise in the heat. Twenty men completed two consecutive 2 h bouts of high-intensity exercise in either hot (n = 12, 40 °C, 40% relative humidity) or mild (n = 8, 24 °C, 21% relative humidity) environments before (PreHA) and after (PostHA) 4 days of 90–120 min of exercise per day in a hot or mild environment. Increased clinical biomarkers of AKI (CLINICAL) was defined as a serum creatinine increase ≥0.3 mg·dL−1 or estimated glomerular filtration rate (eGFR) reduction >25%. Creatinine similarly increased in the hot environment PreHA (0.35 ± 0.23 mg·dL−1) and PostHA (0.39 ± 0.20 mg·dL−1), with greater increases than the mild environment at both time points (0.11 ± 0.07 mg·dL−1, 0.08 ± 0.06 mg·dL−1, p ≤ 0.001), respectively. CLINICAL occurred in the hot environment PreHA (n = 9, 75%), with fewer participants with CLINICAL PostHA (n = 7, 58%, p = 0.007), and no participants in the mild environment with CLINICAL at either time point. Percent change in plasma volume was predictive of changes in serum creatinine PostHA and percent changes in eGFR both PreHA and PostHA. HA did not mitigate reductions in eGFR nor increases in serum creatinine during high-intensity exercise in the heat, although the number of participants with CLINICAL was reduced PostHA. View Full-Text
Keywords: renal function; kidney injury; creatinine; heat stress; acclimation renal function; kidney injury; creatinine; heat stress; acclimation
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MDPI and ACS Style

Pryor, R.R.; Pryor, J.L.; Vandermark, L.W.; Adams, E.L.; Brodeur, R.M.; Schlader, Z.J.; Armstrong, L.E.; Lee, E.C.; Maresh, C.M.; Casa, D.J. Acute Kidney Injury Biomarker Responses to Short-Term Heat Acclimation. Int. J. Environ. Res. Public Health 2020, 17, 1325.

AMA Style

Pryor RR, Pryor JL, Vandermark LW, Adams EL, Brodeur RM, Schlader ZJ, Armstrong LE, Lee EC, Maresh CM, Casa DJ. Acute Kidney Injury Biomarker Responses to Short-Term Heat Acclimation. International Journal of Environmental Research and Public Health. 2020; 17(4):1325.

Chicago/Turabian Style

Pryor, Riana R.; Pryor, J. L.; Vandermark, Lesley W.; Adams, Elizabeth L.; Brodeur, Rachel M.; Schlader, Zachary J.; Armstrong, Lawrence E.; Lee, Elaine C.; Maresh, Carl M.; Casa, Douglas J. 2020. "Acute Kidney Injury Biomarker Responses to Short-Term Heat Acclimation" Int. J. Environ. Res. Public Health 17, no. 4: 1325.

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