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Open AccessArticle

Irradiation with Polychromatic Incoherent Low Energy Radiation of Human Peripheral Blood Mononuclear Cells In Vitro: Effects on Cytokine Production

1
Department of BIOMORF, University of Messina, Via Consolare Valeria, 98125 Messina, Italy
2
Department of MIFT, University of Messina, Viale F. Stagno d’Alcontres, 98166 Messina, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(4), 1233; https://doi.org/10.3390/ijerph17041233
Received: 22 January 2020 / Revised: 7 February 2020 / Accepted: 13 February 2020 / Published: 14 February 2020
(This article belongs to the Special Issue Toxicology and Public Health)
(1) Background: Physical stimuli may activate peripheral blood mononuclear cells (PBMCs) to secrete cytokines, which may favor pro-inflammatory responses or trigger reparative phenomena. The purpose of this study is to evaluate the action of Polarized Polychromatic Incoherent Low Energy Radiation (PILER) on human in vitro PBMCs, by detection of the possible effects on cytokine production; (2) Methods: isolated PBMCs were irradiated with a PILER lamp at different exposure times, at a distance of 10 cm, before incubation. The supernatants were collected after 24 h and 48 h and cytokines evaluated by ELISA; (3) Results: Our results showed a decrease in the levels of pro-inflammatory IL-12p70, IL-17A, IFN-γ, and TNF-α cytokines, whereas IL-10 and TGF-β1 with regulatory activity increased; (4) Conclusions: PILER irradiation affected the cytokine production by isolated PBMCs driving the immune response toward an anti-inflammatory/reparative profile. View Full-Text
Keywords: PILER; PBMCs; Cytokines PILER; PBMCs; Cytokines
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Salmeri, F.M.; Denaro, L.; Ruello, E.; Acri, G.; Gurgone, S.; Sansotta, C.; Testagrossa, B. Irradiation with Polychromatic Incoherent Low Energy Radiation of Human Peripheral Blood Mononuclear Cells In Vitro: Effects on Cytokine Production. Int. J. Environ. Res. Public Health 2020, 17, 1233.

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