Epigenetic Biomarkers for Environmental Exposures and Personalized Breast Cancer Prevention
Department of Epidemiology, UC Irvine School of Medicine, Irvine, CA 92617, USA
Int. J. Environ. Res. Public Health 2020, 17(4), 1181; https://doi.org/10.3390/ijerph17041181
Received: 18 November 2019 / Revised: 7 February 2020 / Accepted: 10 February 2020 / Published: 13 February 2020
(This article belongs to the Special Issue Advancing Primary Prevention of Breast Cancer)
Environmental and lifestyle factors are believed to account for >80% of breast cancers; however, it is not well understood how and when these factors affect risk and which exposed individuals will actually develop the disease. While alcohol consumption, obesity, and hormone therapy are some known risk factors for breast cancer, other exposures associated with breast cancer risk have not yet been identified or well characterized. In this paper, it is proposed that the identification of blood epigenetic markers for personal, in utero, and ancestral environmental exposures can help researchers better understand known and potential relationships between exposures and breast cancer risk and may enable personalized prevention strategies.
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Keywords:
breast cancer; environmental exposures; lifestyle factors; epigenetics; DNA methylation; transgenerational inheritance
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MDPI and ACS Style
Park, H.L. Epigenetic Biomarkers for Environmental Exposures and Personalized Breast Cancer Prevention. Int. J. Environ. Res. Public Health 2020, 17, 1181.
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