Impact of Adverse Drug Reactions in Patients with End Stage Renal Disease in Greece

Spanakis, Marios; Roubedaki, Marianna; Tzanakis, Ioannis; Zografakis-Sfakianakis, Michail; Patelarou, Evridiki; Patelarou, Athina

doi:10.3390/ijerph17239101

Open AccessArticle

Impact of Adverse Drug Reactions in Patients with End Stage Renal Disease in Greece

by

Marios Spanakis

^1,2

,

Marianna Roubedaki

³,

Ioannis Tzanakis

³,

Michail Zografakis-Sfakianakis

¹

,

Evridiki Patelarou

¹ and

Athina Patelarou

^1,*

¹

Department of Nursing, Faculty of Health Sciences, Hellenic Mediterranean University, Estavromenos, GR-71140 Heraklion, Crete, Greece

²

Computational BioMedicine Laboratory, Institute of Computer Science, Foundation for Research and Technology—Hellas (FORTH), GR-70013 Heraklion, Crete, Greece

³

Department of Nephrology, General Hospital of Chania, Meletiou Metaxaki 25, GR-73131 Chania, Crete, Greece

^*

Author to whom correspondence should be addressed.

Int. J. Environ. Res. Public Health 2020, 17(23), 9101; https://doi.org/10.3390/ijerph17239101

Submission received: 8 October 2020 / Revised: 24 November 2020 / Accepted: 2 December 2020 / Published: 6 December 2020

(This article belongs to the Special Issue Chronic Diseases: Biopsychosocial Impact, Interventions and Preventive Measures)

Download

Browse Figures

Versions Notes

Abstract

Background: Patients with end-stage renal disease (ESRD) require specialized therapeutic interventions. The decreased renal function that modulates the physiology and presence of comorbidities is often associated with variations in the pharmacological response, thus increasing the risk of adverse drug events or reactions (ADE/ADRs) from co-administered drugs. Methods: A cross-sectional study to record comorbidities, drug–drug interactions (DDIs), ADE/ADRs in patients with chronic kidney disease of stage five in Greece. The study enrolled 60 patients of mean age 64.8 ± 12.9 years, undergoing hemodialysis three times a week. Demographic and social factors, comorbidities, laboratory test data, medication regimens, DDIs and the reporting of ADE/ADRs were analyzed. Results: Cardiovascular diseases and diabetes were the main comorbidities. In total, 50 different DDIs of various clinical significance were identified. CNS, GI-track, and musculoskeletal-system-related ADE/ADRs were most often reported by patients. ADE/ADRs as clinical outcome from DDIs were associated in 64% of the total identified DDIs. There was a positive trend between number of medications, ADE/ADRs report and DDIs. Conclusions: The impact of ADE/ADRs in ESRD patients should be always considered. Guidelines as well as continuous training in the context of evidence-based clinical practice by healthcare personnel on therapy administration and prevention of adverse events are important.

Keywords: chronic kidney disease; end-stage renal disease; adverse drug reactions; drug–drug interactions; quality of life; chronic disease

Share and Cite

MDPI and ACS Style

Spanakis, M.; Roubedaki, M.; Tzanakis, I.; Zografakis-Sfakianakis, M.; Patelarou, E.; Patelarou, A. Impact of Adverse Drug Reactions in Patients with End Stage Renal Disease in Greece. Int. J. Environ. Res. Public Health 2020, 17, 9101. https://doi.org/10.3390/ijerph17239101

AMA Style

Spanakis M, Roubedaki M, Tzanakis I, Zografakis-Sfakianakis M, Patelarou E, Patelarou A. Impact of Adverse Drug Reactions in Patients with End Stage Renal Disease in Greece. International Journal of Environmental Research and Public Health. 2020; 17(23):9101. https://doi.org/10.3390/ijerph17239101

Chicago/Turabian Style

Spanakis, Marios, Marianna Roubedaki, Ioannis Tzanakis, Michail Zografakis-Sfakianakis, Evridiki Patelarou, and Athina Patelarou. 2020. "Impact of Adverse Drug Reactions in Patients with End Stage Renal Disease in Greece" International Journal of Environmental Research and Public Health 17, no. 23: 9101. https://doi.org/10.3390/ijerph17239101

APA Style

Spanakis, M., Roubedaki, M., Tzanakis, I., Zografakis-Sfakianakis, M., Patelarou, E., & Patelarou, A. (2020). Impact of Adverse Drug Reactions in Patients with End Stage Renal Disease in Greece. International Journal of Environmental Research and Public Health, 17(23), 9101. https://doi.org/10.3390/ijerph17239101

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Impact of Adverse Drug Reactions in Patients with End Stage Renal Disease in Greece

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI