Environmental Epigenetics of Diesel Particulate Matter Toxicogenomics
Abstract
:1. Introduction
2. Materials and Methods
2.1. Cell Culture
2.2. ATAC-Seq Analysis
2.3. Database Analysis
2.4. ATAC-Seq Differential Accessibility Analysis and Visualization
2.5. Genomic Variant Extraction
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Linked Regulatory Region | PubMed_ID | MAPPED_TRAIT | RISK ALLELE | CHR_ID | CHR_POS | p-Valume |
---|---|---|---|---|---|---|
chr2:51031736-51032889 | 30038396 | self-reported educational attainment | rs12620796-A | 2 | 51060711 | 9.00 × 10−11 |
chr5:148730602-148971200 | 30287806 | nicotine dependence symptom count, depressive symptom measurement | rs57108954-T | 5 | 148857822 | 3.00 × 10−6 |
chr5:148730602-148971200 | 26242244 | exploratory eye movement measurement | rs17108911-? | 5 | 148903759 | 6.00 × 10−6 |
chr7:22600600-22602886 | 29071344 | unipolar depression, alcohol dependence | rs2905347-G | 7 | 22580700 | 6.00 × 10−6 |
chr7:116685939-116778343 | 19010793 | multiple sclerosis | rs10243024-? | 7 | 116706549 | 6.00 × 10−6 |
chr8:117846474-117850990 | 30038396 | mathematical ability | rs17430287-A | 8 | 117844068 | 4.00 × 10−8 |
chr9:4506589-4512250 | 29503163 | schizophrenia, response to risperidone | rs16921385-A | 9 | 4507513 | 4.00 × 10−8 |
chr10:88060002-88390829 | 31604244 | multiple sclerosis | rs1819577-A | 10 | 88067364 | 1.00 × 10−7 |
chr10:88060002-88390829 | 30038396 | self-reported educational attainment | rs1426619-T | 10 | 88331783 | 1.00 × 10−11 |
chr10:88060002-88390829 | 30038396 | self-reported educational attainment | rs1426619-T | 10 | 88331783 | 1.00 × 10−10 |
chr11:27720334-28567694 | 30643258 | risk-taking behavior | rs16918024-T | 11 | 28566879 | 8.00 × 10−9 |
chr12:102474603-102536836 | 31676860 | brain volume measurement | rs703545-? | 12 | 102549222 | 1.00 × 10−8 |
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Bilinovich, S.M.; Lewis, K.; Thompson, B.L.; Prokop, J.W.; Campbell, D.B. Environmental Epigenetics of Diesel Particulate Matter Toxicogenomics. Int. J. Environ. Res. Public Health 2020, 17, 7386. https://doi.org/10.3390/ijerph17207386
Bilinovich SM, Lewis K, Thompson BL, Prokop JW, Campbell DB. Environmental Epigenetics of Diesel Particulate Matter Toxicogenomics. International Journal of Environmental Research and Public Health. 2020; 17(20):7386. https://doi.org/10.3390/ijerph17207386
Chicago/Turabian StyleBilinovich, Stephanie M., Kristy Lewis, Barbara L. Thompson, Jeremy W. Prokop, and Daniel B. Campbell. 2020. "Environmental Epigenetics of Diesel Particulate Matter Toxicogenomics" International Journal of Environmental Research and Public Health 17, no. 20: 7386. https://doi.org/10.3390/ijerph17207386