Risk Factors in and Long-Term Survival of Patients with Post-Transplantation Diabetes Mellitus: A Retrospective Cohort Study

Cheng, Ching-Yao; Chen, Cheng-Hsu; Wu, Ming-Fen; Wu, Ming-Ju; Chen, Jun-Peng; Liu, Ying-Mei; Hou, Yu-Chi; Wang, Hue-Yu

doi:10.3390/ijerph17124581

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Risk Factors in and Long-Term Survival of Patients with Post-Transplantation Diabetes Mellitus: A Retrospective Cohort Study

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Department of Pharmacy, Taichung Veterans General Hospital, Taichung 40705, Taiwan

School of Pharmacy, China Medical University, Taichung 40402, Taiwan

Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan

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Department of Life Science, Tunghai University, Taichung 40704, Taiwan

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School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan

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School of Medicine, Chung-Shan Medical University, Taichung 40402, Taiwan

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Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung 40402, Taiwan

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Graduate Institute of Biomedical Science, National Chung Hsing University, Taichung 40227, Taiwan

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Biostatistics Task Force, Taichung Veterans General Hospital, Taichung 40705, Taiwan

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Department of Pharmacy, Chi Mei Medical Center, Tainan City 71004, Taiwan

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Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan

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Int. J. Environ. Res. Public Health 2020, 17(12), 4581; https://doi.org/10.3390/ijerph17124581

Received: 20 May 2020 / Revised: 19 June 2020 / Accepted: 21 June 2020 / Published: 25 June 2020

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Abstract

Post-transplant diabetes mellitus (PTDM) is associated with infection, cardiovascular morbidity, and mortality. A retrospective cohort study involving patients who underwent renal transplantation in a transplantation center in Taiwan from January 2000 to December 2018 was conducted to investigate the incidence and risk factors of PTDM and long-term patient and graft survival rates. High age (45–65 vs. <45 years, adjusted odds ratio (aOR) = 2.90, 95% confidence interval (CI) = 1.64–5.13, p < 0.001), high body mass index (>27 vs. <24 kg/m², aOR = 5.35, 95% CI = 2.75–10.42, p < 0.001), and deceased organ donor (cadaveric vs. living, aOR = 2.01, 95% CI = 1.03–3.93, p = 0.04) were the three most important risk factors for the development of PTDM. The cumulative survival rate of patients and allografts was higher in patients without PTDM than in those with PTDM (p = 0.007 and 0.041, respectively). Concurrent use of calcineurin inhibitors and mammalian target of rapamycin inhibitors (mTORis) decreased the risk of PTDM (tacrolimus vs. tacrolimus with mTORi, aOR = 0.28, 95% CI = 0.14–0.55, p < 0.001). Investigating PTDM risk factors before and modifying immunosuppressant regimens after transplantation may effectively prevent PTDM development. View Full-Text

Keywords: immunosuppressant; post-transplant diabetes mellitus; risk factor; survival rate

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Cheng, C.-Y.; Chen, C.-H.; Wu, M.-F.; Wu, M.-J.; Chen, J.-P.; Liu, Y.-M.; Hou, Y.-C.; Wang, H.-Y. Risk Factors in and Long-Term Survival of Patients with Post-Transplantation Diabetes Mellitus: A Retrospective Cohort Study. Int. J. Environ. Res. Public Health 2020, 17, 4581. https://doi.org/10.3390/ijerph17124581

AMA Style

Cheng C-Y, Chen C-H, Wu M-F, Wu M-J, Chen J-P, Liu Y-M, Hou Y-C, Wang H-Y. Risk Factors in and Long-Term Survival of Patients with Post-Transplantation Diabetes Mellitus: A Retrospective Cohort Study. International Journal of Environmental Research and Public Health. 2020; 17(12):4581. https://doi.org/10.3390/ijerph17124581

Chicago/Turabian Style

Cheng, Ching-Yao, Cheng-Hsu Chen, Ming-Fen Wu, Ming-Ju Wu, Jun-Peng Chen, Ying-Mei Liu, Yu-Chi Hou, and Hue-Yu Wang. 2020. "Risk Factors in and Long-Term Survival of Patients with Post-Transplantation Diabetes Mellitus: A Retrospective Cohort Study" International Journal of Environmental Research and Public Health 17, no. 12: 4581. https://doi.org/10.3390/ijerph17124581

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Risk Factors in and Long-Term Survival of Patients with Post-Transplantation Diabetes Mellitus: A Retrospective Cohort Study

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