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Restless Legs Syndrome across the Lifespan: Symptoms, Pathophysiology, Management and Daily Life Impact of the Different Patterns of Disease Presentation

1
Clinical and Experimental Epileptology and Sleep Disorders Unit, Foundation IRCCS Carlo Besta Neurological Institute, Via Celoria 11, 20133 Milan, Italy
2
Neurology Unit, University Hospital of Ferrara, 44100 Ferrara, Italy
3
Neurophysiopathology Unit, Foundation IRCCS Carlo Besta Neurological Institute, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(10), 3658; https://doi.org/10.3390/ijerph17103658
Received: 2 May 2020 / Revised: 17 May 2020 / Accepted: 18 May 2020 / Published: 22 May 2020
(This article belongs to the Special Issue Sleep Disorders Across the Lifespan: A Different Perspective)
Restless legs syndrome is a common but still underdiagnosed neurologic disorder, characterized by peculiar symptoms typically occurring in the evening and at night, and resulting in sleep disruption and daily functioning impairment. This disease can affect subjects of all age ranges and of both sexes, manifesting itself with a broad spectrum of severity and deserving special attention in certain patient categories, in order to achieve a correct diagnosis and an effective treatment. The diagnosis of restless legs syndrome can be challenging in some patients, especially children and elderly people, and an effective treatment might be far from being easy to achieve after some years of drug therapy, notably when dopaminergic agents are used. Moreover, the pathophysiology of this disorder offers an interesting example of interaction between genetics and the environment, considering strong iron metabolism involvement and its interaction with recognized individual genetic factors. Therefore, this syndrome allows clinicians to verify how lifespan and time can modify diagnosis and treatment of a neurological disorder. View Full-Text
Keywords: restless legs syndrome; sleep; lifespan; age; quality of life; workplace; gender; genetic; environment restless legs syndrome; sleep; lifespan; age; quality of life; workplace; gender; genetic; environment
MDPI and ACS Style

Didato, G.; Di Giacomo, R.; Rosa, G.J.; Dominese, A.; de Curtis, M.; Lanteri, P. Restless Legs Syndrome across the Lifespan: Symptoms, Pathophysiology, Management and Daily Life Impact of the Different Patterns of Disease Presentation. Int. J. Environ. Res. Public Health 2020, 17, 3658. https://doi.org/10.3390/ijerph17103658

AMA Style

Didato G, Di Giacomo R, Rosa GJ, Dominese A, de Curtis M, Lanteri P. Restless Legs Syndrome across the Lifespan: Symptoms, Pathophysiology, Management and Daily Life Impact of the Different Patterns of Disease Presentation. International Journal of Environmental Research and Public Health. 2020; 17(10):3658. https://doi.org/10.3390/ijerph17103658

Chicago/Turabian Style

Didato, Giuseppe, Roberta Di Giacomo, Giuseppa J. Rosa, Ambra Dominese, Marco de Curtis, and Paola Lanteri. 2020. "Restless Legs Syndrome across the Lifespan: Symptoms, Pathophysiology, Management and Daily Life Impact of the Different Patterns of Disease Presentation" International Journal of Environmental Research and Public Health 17, no. 10: 3658. https://doi.org/10.3390/ijerph17103658

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