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Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers

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Department of Environmental Health, Section of Toxicology and Risk Assessment, Norwegian Institute of Public Health, PO Box 222 Skøyen, N-0213 Oslo, Norway
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Départment “Adaption du Vivant“, Physiologie Moléculaire et Adaptation, Muséum National d’Histoire Naturelle, UMR 7221 MNHN/CNRS, 7 rue Cuvier, 75005 Paris, France
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Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail)-UMR_S 1085, F-35000 Rennes, France
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Department of Radiology and Physical Medicine, and Center for Biomedical Research (CIBM), University of Granada, 18016 Granada, Spain
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Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 28029 Madrid, Spain
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Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(10), 3609; https://doi.org/10.3390/ijerph17103609
Received: 29 April 2020 / Revised: 14 May 2020 / Accepted: 15 May 2020 / Published: 21 May 2020
(This article belongs to the Special Issue Impact of Environmental Levels of Bisphenol A on Health)
Bisphenols, particularly bisphenol A (4,4′-(hexafluoroisopropylidene)-diphenol) (BPA), are suspected of inducing oxidative stress in humans, which may be associated with adverse health outcomes. We investigated the associations between exposure to bisphenols and biomarkers of oxidative stress in human studies over the last 12 years (2008‒2019) related to six health endpoints and evaluated their suitability as effect biomarkers. PubMed database searches identified 27 relevant articles that were used for data extraction. In all studies, BPA exposure was reported, whereas some studies also reported other bisphenols. More than a dozen different biomarkers were measured. The most frequently measured biomarkers were 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-OHdG), 8-iso-prostaglandin F2α (8-isoprostane) and malondialdehyde (MDA), which almost always were positively associated with BPA. Methodological issues were reported for MDA, mainly the need to handle samples with caution to avoid artefact formation and its measurements using a chromatographic step to distinguish it from similar aldehydes, making some of the MDA results less reliable. Urinary 8-OHdG and 8-isoprostane can be considered the most reliable biomarkers of oxidative stress associated with BPA exposure. Although none of the biomarkers are considered BPA- or organ-specific, the biomarkers can be assessed repeatedly and non-invasively in urine and could help to understand causal relationships. View Full-Text
Keywords: adverse outcome pathway (AOP); analytical methods; antioxidant; bisphenol F (BPF); bisphenol S (BPS); effect biomarker; HBM4EU; 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA); reactive nitrogen species (RNS); reactive oxygen species (ROS) adverse outcome pathway (AOP); analytical methods; antioxidant; bisphenol F (BPF); bisphenol S (BPS); effect biomarker; HBM4EU; 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA); reactive nitrogen species (RNS); reactive oxygen species (ROS)
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Steffensen, I.-L.; Dirven, H.; Couderq, S.; David, A.; D’Cruz, S.C.; Fernández, M.F.; Mustieles, V.; Rodríguez-Carillo, A.; Hofer, T. Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers. Int. J. Environ. Res. Public Health 2020, 17, 3609.

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